Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of <i>Aspergillus carbonarius</i>
<i>Aspergillus carbonarius</i> is one of the main pathogens responsible for postharvest diseases in fruits and is also one of the main ochratoxin A-producing strains. It not only causes significant economic losses but also poses a risk to human health. We found an inhibitory effect of di...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/17/7/339 |
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| Summary: | <i>Aspergillus carbonarius</i> is one of the main pathogens responsible for postharvest diseases in fruits and is also one of the main ochratoxin A-producing strains. It not only causes significant economic losses but also poses a risk to human health. We found an inhibitory effect of dimethyl fumarate fumigation on the growth of <i>A. carbonarius</i>. To further explore its antifungal mechanism, this study elucidated the functions of key pathway-related genes through a transcriptomics analysis. A total of 1402 differentially expressed genes (DEGs) were identified, including 987 up-regulated and 415 down-regulated genes. Dimethyl fumarate was found to significantly inhibit the growth of <i>A. carbonarius</i> by disrupting cell integrity and obstructing mycelium growth and secondary metabolism. These findings provide a basis for the potential application of dimethyl fumarate in the food industry to inhibit <i>A. carbonarius</i> and subsequent ochratoxin A contamination. |
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| ISSN: | 2072-6651 |