Antimicrobial Peptides SET-M33L and SET-M33L-PEG Are Promising Agents Against Strong Biofilm-Forming P. aeruginosa, Including Multidrug-Resistant Isolates

Background: The antimicrobial peptides (AMPs) SET-M33L and SET-M33L-PEG were investigated against 10 clinical isolates of P. aeruginosa. Methods: Their minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), and m...

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Bibliographic Details
Main Authors:	Alessio Fontanot, Peter D. Croughs, Clelia Cortese, Adrianus C. J. M. de Bruijn, Chiara Falciani, Alessandro Pini, Isabella Ellinger, Wendy W. J. Unger, John P. Hays
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Antibiotics
Subjects:	<i>Pseudomonas aeruginosa</i> biofilm antimicrobial peptides multidrug resistance SET-M33L SET-M33L-PEG
Online Access:	https://www.mdpi.com/2079-6382/14/7/699
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Summary:	<b>Background</b>: The antimicrobial peptides (AMPs) SET-M33L and SET-M33L-PEG were investigated against 10 clinical isolates of <i>P. aeruginosa</i>. <b>Methods</b>: Their minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), and minimum biofilm inhibitory concentrations (MBICs) were evaluated against tobramycin, ceftazidime, and polymyxin B. <b>Results</b>: MICs and MBCs were 7- to 100-fold lower than tobramycin, and 10- to 300-fold lower than ceftazidime. Fractional inhibitory concentration (FIC) indices showed an additive effect, while fractional bactericidal concentration (FBC) indices showed synergistic effects (FBC < 0.5) for most isolates. <b>Conclusion</b>: SET-M33L and SET-M33L-PEG are promising antimicrobial agents against strong biofilm-forming <i>P. aeruginosa</i>, including MDR isolates.
ISSN:	2079-6382

Antimicrobial Peptides SET-M33L and SET-M33L-PEG Are Promising Agents Against Strong Biofilm-Forming <i>P. aeruginosa</i>, Including Multidrug-Resistant Isolates

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