Clonal hematopoiesis of indeterminate potential and heart failure
Modern studies demonstrate that clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for the development and prognosis of heart failure (HF) of various origin. The pathophysiology and consequences of CHIP are gene-specific. The mechanisms involved in this process are complex and i...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2024-12-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/6016 |
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| Summary: | Modern studies demonstrate that clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for the development and prognosis of heart failure (HF) of various origin. The pathophysiology and consequences of CHIP are gene-specific. The mechanisms involved in this process are complex and indicate the central role of systemic and myocardial inflammation, including the immune response dependent on the inflammasome/interleukin-1β/interleukin-6 cascade. CHIP and associated inflammatory pathways represent a powerful potential target, which rationales the research in the area of various HF stages and markers of this genetic phenomenon. A better understanding of the interactions between mutant clones, immune pathways, chronic inflammation and clinical implementation in HF may be important in the context of precision and personalized medicine. |
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| ISSN: | 1560-4071 2618-7620 |