CellMemory: hierarchical interpretation of out-of-distribution cells using bottlenecked transformer
Abstract Machine learning methods, especially Transformer architectures, have been widely employed in single-cell omics studies. However, interpretability and accurate representation of out-of-distribution (OOD) cells remains challenging. Inspired by the global workspace theory in cognitive neurosci...
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Main Authors: | Qifei Wang, He Zhu, Yiwen Hu, Yanjie Chen, Yuwei Wang, Guochao Li, Yun Li, Jinfeng Chen, Xuegong Zhang, James Zou, Manolis Kellis, Yue Li, Dianbo Liu, Lan Jiang |
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Format: | Article |
Language: | English |
Published: |
BMC
2025-06-01
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Series: | Genome Biology |
Online Access: | https://doi.org/10.1186/s13059-025-03638-y |
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