Magnetic Resonance Imaging and X-Ray Imaging Properties of Ultrasmall Lanthanide Oxide (Ln = Eu, Gd, and Tb) Nanoparticles Synthesized via Thermal Decomposition
Owing to their 4f electrons and high atomic numbers, lanthanide (Ln) elements impart lanthanide oxide (Ln<sub>2</sub>O<sub>3</sub>) nanoparticles with excellent biomedical imaging properties. This study reports synthesis for three types of ultrasmall and monodisperse Ln<su...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/12/2519 |
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| Summary: | Owing to their 4f electrons and high atomic numbers, lanthanide (Ln) elements impart lanthanide oxide (Ln<sub>2</sub>O<sub>3</sub>) nanoparticles with excellent biomedical imaging properties. This study reports synthesis for three types of ultrasmall and monodisperse Ln<sub>2</sub>O<sub>3</sub> nanoparticles (Ln = Eu, Gd, and Tb) via thermal decomposition in oleylamine at 280 °C, followed by ligand exchange with citric acid (CA) to produce water-dispersible, CA-grafted Ln<sub>2</sub>O<sub>3</sub> nanoparticles with high colloidal stability. The resulting CA-grafted Ln<sub>2</sub>O<sub>3</sub> nanoparticles had average diameters of approximately 2 nm. We characterized their physicochemical properties, including in vitro cytotoxicity, magnetic resonance imaging properties (i.e., water proton spin relaxivities), and X-ray imaging properties (i.e., X-ray attenuation). |
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| ISSN: | 1420-3049 |