VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER

VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER

Abstract. Angiogenesis plays the major role in growth, progression and metastasis of different solid umors. Vascular endothelium growth factor (VEGF) is a basic factor of angiogenesis regulation. The aim of present study was to evaluate possible correlations between C-2578A and C+936T VEGFА gene fun...

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Bibliographic Details
Main Authors: A. V. Shevchenko, V. I. Konenkov, O. V. Golovanova, A. E. Blagodatskikh, E. Yu. Garbukov, M. N. Stakheeva
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
Series:Медицинская иммунология
Subjects:
breast cancer
vegfa gene polymorphism
lymphogenic metastases
menstrual status
Online Access:https://www.mimmun.ru/mimmun/article/view/301
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Summary:Abstract. Angiogenesis plays the major role in growth, progression and metastasis of different solid umors. Vascular endothelium growth factor (VEGF) is a basic factor of angiogenesis regulation. The aim of present study was to evaluate possible correlations between C-2578A and C+936T VEGFА gene functional polymorphisms, and risk of breast cancer development. An association of -2578AA and -2578СС /+936СС VEGFA polymorphisms with incidence of breast cancer was revealed in our study. Distinct features of VEGFA genotype distribution were found for women with lymphogenic metastases and differences in menstrual status.
ISSN:1563-0625
2313-741X

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