α-Glucosidase inhibitory activity of polyphenol-rich sugarcane extract: screening and mechanistic insights based on biolayer interferometry-mass spectrometry

α-Glucosidase inhibitory activity of polyphenol-rich sugarcane extract: screening and mechanistic insights based on biolayer interferometry-mass spectrometry

IntroductionPolyphenol-rich sugarcane extract (PRSE) contains bioactive compounds with potential hypoglycemic properties, but its direct interaction with α-glucosidase has not been explored.MethodsThis study investigated the inhibitory mechanism of PRSE on α-glucosidase using enzyme kinetics. Bioact...

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Bibliographic Details
Main Authors: Mengli Yao, Jia Liu, Fang Zhou, Haizhi Li, Ruoyong Wang, Zhong Han, Jie Liu, Wei Chen, Guoyu Liu, Shuheng Yang, Shenlin Duan, Xiaofeng Han, Peng Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Nutrition
Subjects:
polyphenol-rich sugarcane extract
α-glucosidase inhibition
bioactive compounds
BLI-MS
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1575409/full
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