Modulating the Gut–Muscle Axis: Increasing SCFA-Producing Gut Microbiota Commensals and Decreasing Endotoxin Production to Mitigate Cancer Cachexia

Modulating the Gut–Muscle Axis: Increasing SCFA-Producing Gut Microbiota Commensals and Decreasing Endotoxin Production to Mitigate Cancer Cachexia

Cancer cachexia is a multi-organ and multifactorial syndrome characterized by muscle wasting (with or without adipose tissue loss) and systemic inflammation in patients with advanced malignancies. Gut microbiota dysbiosis, particularly the depletion of short-chain fatty acid (SCFA)-producing bacteri...

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Bibliographic Details
Main Authors: Sagnik Roy, Amir Hossein Alizadeh Bahmani, Mark Davids, Hilde Herrema, Max Nieuwdorp
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Microorganisms
Subjects:
cancer cachexia
gut microbiota
dysbiosis
short-chain fatty acids (SCFAs)
branched chain amino acids (BCAAs)
bile acids
Online Access:https://www.mdpi.com/2076-2607/13/6/1356
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