The Involvement of the ERK-Hypoxia-Angiogenesis Signaling Axis and HIF-1 in Hepatocellular Carcinoma

QR Code

The Involvement of the ERK-Hypoxia-Angiogenesis Signaling Axis and HIF-1 in Hepatocellular Carcinoma

None

Saved in:

Bibliographic Details
Main Authors:	Mylonis, Ilias, Simos, George
Format:	Electronic Book Chapter
Language:	English
Published:	IntechOpen 2012
Subjects:	Health Sciences
Online Access:	https://www.intechopen.com/chapters/28027
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Cobalt Chloride-simulated Hypoxia Promoted Ossification of the Posterior Longitudinal Ligament Through the HIF1A–BMP4 Axis
by: Shihao Lu, et al.
Published: (2025-06-01)

The VHL-HIF Signaling in Renal Cell Carcinoma: Promises and Pitfalls
by: Morais, Christudas, et al.
Published: (2012)

Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models
by: Masahiro Matsuki, et al.
Published: (2018-06-01)

HIF1α-PHD1-FOXA1 Axis Orchestrates Hypoxic Reprogramming and Androgen Signaling Suppression in Prostate Cancer
by: Limiao Liang, et al.
Published: (2025-07-01)

THE ROLE OF HYPOXIA-INDUCED FACTOR-1 (HIF-1) IN CYTOPROTECTION EFFECT IN ISCHEMIC AND PHARMACOLOGIC POSTCONDITIONING
by: N. S. Shcherbak, et al.
Published: (2014-11-01)

Hypoxia-inducible factors: details create a picture. Part I. HIF-1
by: G. A. Ignatenko, et al.
Published: (2023-09-01)

Activation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway
by: Qing-Feng Xiang, et al.
Published: (2019-12-01)

Targeting enabled homolog with daunorubicin inhibits ERK1/2/c‐Fos pathway and suppresses hepatocellular carcinoma progression
by: Zhi‐Mei Li, et al.
Published: (2025-06-01)

Hypoxia-Regulated Pro- and Anti-Angiogenesis in the Heart
by: Messmer-Blust, Angela, et al.
Published: (2012)

Intermittent hypoxia aggravates asthma inflammation via NLRP3/IL-1β-dependent pyroptosis mediated by HIF-1α signalling pathway
by: Ling Zhou, et al.
Published: (2025-07-01)

Mechanism of Hypoxia-Inducible Factor-1alpha Over- Expression and Molecular-Target Therapy for Hepatocellular Carcinoma
by: Yao, Dengfu, et al.
Published: (2011)

RETRACTED: Inhibition of ERK pathway decreases the synovial hyperplasia and angiogenesis of rheumatoid arthritis rats
by: Haisheng Hu, et al.
Published: (2018-10-01)

PKN2 Inhibits VEGFA and bFGF‐Mediated Angiogenesis by Targeting HIF‐1α in Colon Cancer
by: Yun Zhu, et al.
Published: (2025-07-01)

Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition
by: Ming Ye, et al.
Published: (2017-06-01)

Hypoxia effect on proliferative activity of cells in orthotopic xenograft of hepatocellular carcinoma of the liver in the experiment
by: T. M. Kecheryukova, et al.
Published: (2024-05-01)

Hypoxia-inducible factors: details create a picture. Part II. HIF-2
by: G. A. Ignatenko, et al.
Published: (2024-01-01)

Involvement of the ERK MAPK Cascade in the Formation of Adhesions in the Abdominal Cavity
by: I. A. Shurygina, et al.
Published: (2021-01-01)

ROS-Responsive Nanosystem Targeted Co-Delivery YC-1 and Regorafenib to Alleviate Hypoxia Enhancing Hepatocellular Carcinoma Therapy
by: Song L, et al.
Published: (2025-07-01)

Clinical significance of expression of the marker of adaptation to hypoxia HIF-1α in pregnant women with initial forms of venous disease
by: E. Iu. Iupatov, et al.
Published: (2021-07-01)

A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma
by: Yue Fu, et al.
Published: (2025-07-01)

THE ROLE OF ENDOTHELIN-1, HIF1α, HIF2α IN RETINAL VEIN OCCLUSION
by: M. V. Budzinskaya, et al.
Published: (2019-02-01)

Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma
by: Eliane Macedo Sobrinho Santos, et al.
Published: (2017-04-01)

Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis.
by: Riya Ghosh, et al.
Published: (2025-06-01)

Arsenic trioxide inhibits angiogenesis of hepatocellular carcinoma after insufficient radiofrequency ablation via blocking paracrine angiopoietin-1 and angiopoietin-2
by: Shuying Dong, et al.
Published: (2022-12-01)

ERK1/2 Signaling in Intrahepatic Cholangiocarcinoma: From Preclinical Advances to Therapeutic Strategies
by: Veronica Porreca, et al.
Published: (2025-06-01)

Angiogenesis: signaling pathways and their inhibitors
by: Ksenia L. Markova, et al.
Published: (2019-08-01)

Isoliensinine Induces Ferroptosis in Urothelial Carcinoma Cells via the PI3K/AKT/HIF-1α Axis: Molecular Evidence from Next-Generation Sequencing
by: Yun-Chen Li, et al.
Published: (2025-07-01)

Tanshinone IIA alleviates liver fibrosis by suppressing hepatic stellate cell proliferation via ERK/cyclin D1/p-Smad3L signaling axis
by: Wenjing Liao, et al.
Published: (2025-05-01)

Intratumor Rhodococcus sp. B513 drives DEN-induced hepatocellular carcinoma progression by modulating gut microbiota and angiogenesis
by: Qisha Liu, et al.
Published: (2025-01-01)

A novel peptide from yak ameliorates hypoxia-induced cardiac dysfunction via targeting gut microbiota and HIF-1α pathway
by: Feiyan Yang, et al.
Published: (2025-08-01)

Author Correction: MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity
by: Mi Yang, et al.
Published: (2025-06-01)

LncRNA HIF1A-AS1 promotes the proliferation of gastric cancer cell lines through interfering with HIF1A
by: YIN Lijun, BO Yang, Anggelema, SONG Linlin
Published: (2025-05-01)

MAPK/ERK signaling pathway in rheumatoid arthritis: mechanisms and therapeutic potential
by: Jun Xie, et al.
Published: (2025-07-01)

Vitamin D Alleviates Osteoarthritis Progression by Targeting Cartilage and Subchondral Bone via Myd88-TAK1-ERK Axis Suppression
by: Gao X, et al.
Published: (2025-07-01)

The role of miRNA genes participating in VHL-HIF1α in clear cell renal cell carcinoma
by: V. N. Pavlov, et al.
Published: (2019-02-01)

HIF-2α not HIF-1α overexpression confers poor prognosis in non–small cell lung cancer
by: Zhao-Jia Gao, et al.
Published: (2017-06-01)

Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathway
by: Hailiang Yu, et al.
Published: (2019-12-01)

Beyond VEGF: The NOTCH and ALK1 Signaling Pathways as Tumor Angiogenesis Targets
by: Nolan-Stevaux, Olivier, et al.
Published: (2012)

RETRACTED ARTICLE: Ras-ERK signalling represses H1.4 phosphorylation at serine 36 to promote non-small-cell lung carcinoma cells growth and migration
by: Shaomin Shi, et al.
Published: (2019-12-01)

Deciphering adenosine signaling in hepatocellular carcinoma: Pathways, prognostic models, and therapeutic implications
by: Huihai Yang, et al.
Published: (2025-07-01)