Torthaí cuardaigh - Ziyun Hu
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Predictive value of lactate levels for mortality in pneumonia: a systematic review and meta-analysis
Foilsithe / Cruthaithe 2025-06-01Faigh an téacs iomlánIntroduction: Lactate levels, a marker of tissue hypoxia and metabolic acidosis, have been suggested as a prognostic indicator for patient outcomes in pneumonia. This systematic review and meta-analysis aim to determine the predictive value of lactate levels for mortality in patients with pneumonia...
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OTUB1-SLC7A11 Axis Mediates 4-Octyl Itaconate Protection Against Acetaminophen-Induced Ferroptotic Liver Injury
Foilsithe / Cruthaithe 2025-06-01Faigh an téacs iomlánFerroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, plays a crucial role in acetaminophen (APAP)-induced hepatotoxicity. While 4-octyl itaconate (4-OI) demonstrates protective effects against APAP toxicity, its molecular mechanisms remain to be fully eluc...
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ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling
Foilsithe / Cruthaithe 2025-12-01Faigh an téacs iomlánObjectives Recent studies have highlighted the strong association between kidney disease and ferroptosis. However, the role of ferroptosis in diabetic nephropathy (DN) remains unclear. This study aimed to determine the role of ACSF2 in renal tubule injury in DN and its underlying mechanisms.Methods...
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