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    Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy

    Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy by Kemiao Pang, Jiayi Huang, Shiwu Zhang, Yinghui Guan, Ning Zou, Jiaxin Kang, Haining Du, Dechao Zhao, Denis V. Abramochkin, Heyu Chen, Nan Zhang, Yunyan Gu, Ning Liu, Yining Niu, Ziqi Xiong, Xueya Zhang, Fanghao Lu, Huitao Fan, Jinwei Tian, Bo Yu, Shuijie Li, Weihua Zhang

    Published 2025-09-01

    Diabetic angiopathy, a major complication of type 2 diabetes mellitus (T2DM), is driven by vascular dysfunction, metabolic reprogramming, and oxidative stress. NAD+-dependent deacetylase SIRT6, located in the nucleus, is recognized for its role in modulating cardiovascular and metabolic homeostasis...

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