Search Results - Zhihong Wu

As the global urbanization process accelerates, rural settlements in China are facing the challenges of rural hollowing and widening urban–rural disparities. The establishment of the national scenic area system has made scenic settlements a primary direction for tourism development. However, industr...

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Cepharanthine (CEP) is a natural bisbenzylisoquinoline alkaloid known for its antibacterial, antiviral, and anti-inflammatory activities. Its antifungal effect, however, has not been well studied. In this work, we used machine learning-based virtual screening with Random Forest, Neural Network, and...

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Fumarase plays a pivotal role in the tricarboxylic acid cycle, but its functions in plant pathogenic fungi are not well understood. We identified two fumarase genes in <i>Fusarium proliferatum</i> and generated individual deletion mutants. Loss of <i>FpFumB</i> led to defects...

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Abstract To identify ferroptosis markers, which were associated with prognosis and immune response in colorectal cancer (CRC), we integrated spatial transcriptome, single-cell transcriptome, and bulk transcriptome data for analysis, and this multi-omics integration approach is an innovation that dis...

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ABSTRACT Objectives B3GALT6 ‐related disorders are characterized by severe early‐onset spinal deformities requiring surgical corrections but are associated with increased risks of perioperative complications. This study reports the clinical experience and outcomes of selecting the substantially touc...

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<b>Background</b>: With the intensification of population aging, osteoporosis has become one of the significant public health issues affecting human health. Currently available medications for treating osteoporosis are associated with various adverse effects and resistance issues. Oligon...

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Abstract Background Multi‐omics features of cell‐free DNA (cfDNA) can effectively improve the performance of non‐invasive early diagnosis and prognosis of cancer. However, multimodal characterization of cfDNA remains technically challenging. Methods We developed a comprehensive multi‐omics solution...

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Idiopathic scoliosis (IS) is the most common form of spinal deformity with unclear pathogenesis. In this study, we first reanalyzed the loci associated with IS, drawing upon previous studies. Subsequently, we mapped these loci to candidate genes using either location-based or function-based strategi...

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