Søgeresultater - Yuqing Chen
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Smurf2 knockdown attenuates the progression of diabetic nephropathy by inhibiting mesangial cell proliferation and fibrosis through suppressing EYA2 ubiquitination
Udgivet 2025-12-01Få fuldtekstDiabetic nephropathy (DN) is a serious microvascular complication of diabetes and the main cause of end-stage renal disease. Smurf2 is a member of ubiquitin ligases. In this study, we aimed to investigate the mechanism by which Smurf2 mediated the development of DN. C57BL/6 mice were intraperitoneal...
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A novel guiding device for puncture localization in percutaneous transforaminal endoscopic discectomy
Udgivet 2025-06-01Få fuldtekstAbstract Background Conventional fluoroscopy-based positioning techniques for percutaneous transforaminal endoscopic discectomy (PTED) depend heavily on the operator’s spatial cognition and surgical expertise, typically necessitating multiple puncture attempts under iterative radiographic monitoring...
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The effect of virtual endoscopy simulator training on novices: a systematic review.
Udgivet 2014-01-01Få fuldtekst<h4>Background</h4>Advances in virtual endoscopy simulators have paralleled an interest in medical simulation for gastrointestinal endoscopy training.<h4>Objective</h4>The primary objective was to determine whether the virtual endoscopy simulator training could improve the pe...
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Bibliometric analysis of global research trends in pancreatic cancer immunotherapy
Udgivet 2025-12-01Få fuldtekstPancreatic cancer is a highly malignant tumor with poor prognosis and limited treatments. Immunotherapy shows promise in improving outcomes, but bibliometric analyses in this field are scarce. Our work reveals emerging trends, identifies research gaps, and highlights shifts in focus, offering valuab...
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Decoding colorectal cancer lung metastasis: a global research odyssey
Udgivet 2025-07-01Få fuldtekstBackgroundColorectal cancer (CRC) remains a major global health burden, particularly when complicated by pulmonary metastasis (PM), which significantly worsens prognosis and reduces survival despite active treatment. The absence of standardized therapeutic strategies for CRC with PM has driven resea...
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Evaluation of a novel approach for colorectal cancer screening using an intelligent tool (INTEL-PATH CRC): a protocol for a multicentre, real-world, cohort study
Udgivet 2025-07-01Få fuldtekstIntroduction Traditional colorectal cancer (CRC) screening programmes in China face two major challenges: low screening coverage and poor adherence. Mobile health shows promise for cancer prevention, and a WeChat-based intelligent tool has been developed to support full-cycle CRC screening, includin...
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Disturbance of gut microbiota in diabetes related macroangiopathy: Evidence from the gut bacteriome and mycobiome
Udgivet 2025-07-01Få fuldtekstSummary: Diabetes related macroangiopathy (DMA) is a major complication of type 2 diabetes (T2D), impacting both morbidity and mortality. This study characterized the gut bacteriome and mycobiome in 179 adults, including 58 with DMA, 71 with T2D, and 50 healthy controls. The gut microbiome of DMA su...
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