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    Single-cell sequencing revealed the recurrence causes of ETV6:RUNX1 fusion-positive B-ALL in children

    Single-cell sequencing revealed the recurrence causes of ETV6:RUNX1 fusion-positive B-ALL in children by Guotao Guan, Xiuxiu Wang, Xiuxin Li, Qi Wang, Xiuli Li, Xiaojun Sun, Liying Liu, Yunfeng Lu, Bingju Liu, Xinyu Li, Ping Zhao, Fei Gao, Lijun Chen, Lihua Zhao, Yunpeng Dai

    Published 2025-10-01

    Objective: The ETV6RUNX1 fusion is the most common genetic abnormality in childhood B-cell acute lymphoblastic leukemia (B-ALL), yet nearly 50 % of relapses occur in patients initially classified as low-risk with this alteration. This study aimed to unravel the underlying pathways driving relapse in...

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