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    Shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells and augment bone regeneration

    Shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells and augment bone regeneration by Huaqian Liu, Weiwei Zhao, Yuhe Yang, Ho-Pan Bei, Qunchao Chen, Xintong Zhou, Yuanchi Zhang, Chunyi Wen, Yuefeng Hao, Jinlian Hu, Yaxiong Liu, Yu Zhang, Ka-Hing Wong, Hongyu Zhang, Xin Zhao

    Published 2025-11-01

    Metallic bone screws are clinically used to fix the fractured bone fragments in bone defect treatment; yet they present compromised therapeutic efficacy due to poor osseointegration and tissue support. Here, we develop a novel thermoresponsive shape memory (SMP) bone screw with osteogenesis-angiogen...

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