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    Senescence-associated signature based on immunotherapy response sequencing reveals PPIL3 as target for bladder cancer treatment and prognosis prediction

    Senescence-associated signature based on immunotherapy response sequencing reveals PPIL3 as target for bladder cancer treatment and prognosis prediction by Kaixuan Du, Kaixuan Du, Ning Kang, Ning Kang, Yuda Lin, Yuda Lin, Kaipeng Jia, Kaipeng Jia, Chong Shen, Chong Shen, Zhouliang Wu, Zhouliang Wu, Hailong Hu, Hailong Hu

    Published 2025-06-01

    BackgroundBladder cancer (Bca) remains a major genitourinary malignancy with unmet needs in immunotherapy optimization. Despite advancements in immune checkpoint inhibitors (ICIs), challenges persist, including low response rates and drug resistance. Emerging evidence links tumor cell senescence to...

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