Rezultaty - Yuanyuan Xie
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Clinical characteristics of bronchopulmonary dysplasia and the risk of sepsis onset prediction via machine learning models
Wydane 2025-06-01Dokumenty pełnotekstoweBronchopulmonary dysplasia (BPD), also known as chronic lung disease, is the most common cause of respiratory morbidity in preterm infants. Sepsis plays a significant role in the pathogenesis of BPD, and the systemic inflammatory response caused by sepsis is associated with lung development, leading...
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Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity
Wydane 2023-12-01Dokumenty pełnotekstoweAspartic acid (Asp) isomerization is a spontaneous non-enzymatic post-translation modification causing a change in the structure of the protein backbone, which is commonly observed in therapeutic antibodies during manufacturing and storage. The Asps in Asp–Gly (DG), Asp–Ser (DS), and Asp–Thr (DT) mo...
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Accelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies
Wydane 2023-12-01Dokumenty pełnotekstowePharmaceutical companies have recently focused on accelerating the timeline for initiating first-in-human (FIH) trials to allow quick assessment of biologic drugs. For example, a stable cell pool can be used to produce materials for the toxicology (Tox) study, reducing time to the clinic by 4–5 mont...
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