Search Results - Yu. V. Lukina

Results of the control randomized studies in 2009: what is new in cardiology.

Data of evidence based cardiology including results of international clinical trials on efficacy and safety of the modern calcium channel blocker (CCB), lercanidipine, are presented. Results of these trials show the firm position of lercanidipine in the modern cardiology and confirm that treatment w...

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Congress of the American College of Cardiology 2010: crisis of clinical guidelines.

Data of evidence-based cardiology and clinical guidelines that define the position of combined therapy to achieve the targets of hypertension (HT) treatment (achievement and maintenance of the target blood pressure (BP) level, protection of the target organs, improvement of the quality of life in hy...

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Data of the evidence based medicine about bisoprolol treatment of patients with cardiovascular diseases (arterial hypertension, ischemic heart disease, chronic heart failure, rhythm disorders) are presented. Implementation of bisoprolol generics as well as bisoprolol usage in smoking cardiovascular...

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The main objectives and strategies for treatment of atrial fibrillation (AF), one of the most common cardiac arrhythmia, are seen. A combination of strategies for heart rate control in patients with atrial fibrillation receiving rhythm-controling therapy is preferred at present, according to current...

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The problem of varenicline use in patients with cardiovascular diseases is discussed. Results of large clinical trials and meta-analyses with varenicline have proven its high efficacy for treatment of nicotine addiction in adults and a small number of side events. Varenicline is the main agent for p...

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Main principles of chronic heart failure (CHF) management are presented, including the role of beta-adrenoblockers (BB), in particular, bisoprolol. BB potential as initial CHF treatment is discussed.

Arterial hypertension (AH) is reviewed as the leading cause of cardiovascular disease mortality. The authors stress target blood pressure level achievement as the crucial factor in effective prevention of AH complications. Typically, the latter is possible only with combined pharmaceutical therapy....

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Aim. To perform a pharmacoeconomical assessment of the use of generic statin drugs in patients with high and very high cardiovascular risk (CVR) in real clinical practice based on the data of the study PRIORITY.Material and methods. The PRIORITY study included 298 patients with high (29; 9.7%) and v...

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Aim. To study efficacy and safety of calcium channel blocker, S-amlodipine, in combination with β-blocker, atenolol, in patients with arterial hypertension (HT) 1-2 degree com- pared to fixed combination of racemic amlodipine and atenolol.Material and methods. Patients (n=31, 7 men and 24 women) wit...

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The paper summarizes the specific features of post-marketing studies, which are performed after the medication registration, in the settings close to the real-world clinical practice. In particular, the authors discuss the design and results of the Russian post-marketing study of nifedipine CR (cont...

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Methods that allow to systematize the accumulated information on specifically formulated questions, analyze it and make reliable findings are of great interest and popularity with the emergence of a huge number of studies and publications in various fields of medicine, a significant increase in info...

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Basic principles of beta-blockers choice strategy are presented. Attention is focused on the facts concerning the evidence base for effects of various beta-blockers on the outcomes of cardiovascular diseases. Beta-blocker indications and safety of their long-term use are considered from this point o...

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The problem of adherence remains one of the currently important and at the same time the most difficult one to solve for modern medicine and society. Despite five decades of scientific research on this issue, numerous attempts to create reliable diagnostic tests, the search for methods to increase p...

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One of the most common tests for evaluating of medication adherence – 4-question scale Moriscos-Green – is considered. Advantages (flexibility, conciseness) and disadvantages (insufficient sensitivity and specificity) of this test are presented. Disadvantages of 4-question version of the test were c...

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The role of randomized controlled trials (RCTs) and observational studies in evaluation of the efficacy and safety of drugs in cardiology is discussed. The possibility of using the results of non-interventional studies in accepting the decision to choose the most effective and safe drug is presented...

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The treatment  adherence problem  is one  of the  most  significant for medicine and society. The article focuses  on the main aspects of the adherence problem: modern view on terminology of this issue, various factors classification influencing adherence, diagnostics  of adherence. A  review is pre...

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The article is devoted to the issue of drug interactions in the combination regimens. Today, when drug therapy is the first-line approach for patients with noncommunicable diseases, and the world population ageing leads to an increase in the number of patients with severe comorbidity and polypharmac...

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Working Group of the NIKEA Study. Yekaterinburg: Akulina E.N., Reznik I.I.; Izhevsk: Grebnev S.A., Yezhov A., Shinkareva S.E.; Krasnodar: Kudryashov E.A., Skibitsky A.V., Skibitsky V.V., Fendrikova A.V.; Krasnoyarsk: Altayev V.D., Matyushin G.V., Nemik D.B., Pitaev R.R., Samokhvalov E.V., Stolbikov...

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