Risultati della ricerca - Yu. V. Kotovskaya

Pathophysiologic mechanisms of central aortal pressure (CAP) are more complex than those of peripheral pressure, measured at brachial artery level. CAP indirectly reflects the state of circulatory system as a whole, since it is modulated by aorta elasticity, as well as structure and function of midd...

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The ageing is the main risk factor for arterial hypertension (AH) and cardiovascular diseases. Natural ageing with normal BP is followed by changes in large arteries (rigidity), myocardium (hypertrophy) and diastolic relaxation and filling of cardiac muscle (diastolic dysfunstion). In AH these chang...

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In spite of the fact that clinical measurement of blood pressure which meets methodical requirements is still a basis for diagnostics of arterial hypertension and assessment of treatment efficiency, it is widely recognized that proper diagnostics and management of patients with arterial hypertension...

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Aim. To assess the risk of fatal cardiovascular (CVD) events in medical doctors of various specialities, using modern risk scales, and to identify the target groups for primary prevention with a fixed-dose combination of enalapril / hydrochlorothiazide (HCT) and simvastatin. Material and methods. Th...

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Aim. As a part of ARGUS-2 program, to demonstrate the reserves for arterial hypertension (AH) control improvement, by rational monotherapy or combined therapy with diuretics in patients with uncontrolled AH in anamnesis: individuals with isolated systolic AH (ISAH), diabetes mellitus (DM), chronic n...

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This literature review is focused on the modern diagnostic methods in pre-clinical renal pathology. The wide prevalence of renal dysfunction in cardiovascular disease (CVD), its role in the stratification of cardiovascular and renal complication risk, and the potential for medical prevention of thes...

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Aim. A systematic review of studies on pulmonary hypertension (PH) cost estimates.Material and methods. A systematic literature search was performed for studies assessing the cost of PH published up to November 30, 2023. The search was carried out in the PubMed/MEDLINE, EMBACE databases for publicat...

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Decrease of blood pressure (BP) and its maintenance on target level is the main factor for cardiovascular mortality and morbidity reduction in hypertensive patients. For effective BP decrease most patients need combination therapy. The article is focused on benefits and adverse events of some combin...

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Aim. To assess middle-size vessel wall status, by volume compression oscillometry method, in patients with arterial hypertension (AH) and various variants of left ventricular (LV) remodeling. Material and methods. The study included 112 patients (44 males; mean age 53.5±11.1 years) with AH and repro...

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The basis for the successful treatment of any disease is a clear understanding of its cause, the mechanisms of its development, and their relationship to symptoms. The article considers one of the links in the pathogenesis of arterial hypertension - an increase in the activity of the sympathetic ner...

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Aim. To assess the impact of frailty syndrome (FS) on the risk of myocardial infarction (MI) and atrial fibrillation (AF) in people aged ≥65 years.Material and methods. A prospective cohort study of a random sample of a free-living population aged ≥65 years (n=611). Measurement of blood pressure, an...

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The heart is related with vascular system anatomically and functionally. Structural and functional changes in the arterial bed increase afterload on the left ventricle (LV), and can change its function, leading to the restructuring of the LV adaptation. Systolic blood pressure (SBP) in the aorta, di...

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Aim. To study the effects of an angiotensin II receptor antagonist (ARA II) valsartan, a statin (fluvastatin XL), and their combination on endothelial function (EF) in patients with arterial hypertension (AH) and dyslipidemia (DLP).Material and methods. In total, 30 patients with untreated, non-comp...

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Elderly population is heterogenic, and persons with the same chronological age differ greatly by their physical and cognitive functioning. Regardless the convincing witness on the adverse influence of raised blood pressure (BP) in a middle age persons, its influence on the prognosis of a very old is...

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The recently emerged concept of cardio-reno-metabolic continuum supports common pathogenesis, development and progression risk factors (RF) for renal dysfunction and cardiovascular disease (CVD), as well as the importance of renal dysfunction, from subclinical disturbances to terminal renal failure,...

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Aim. Pulse wave velocity (PWV) is a classic index for arterial and aortal elasticity assessment. Aortal PWV is a strong independent predictor of cardiovascular mortality in patients with arterial hypertension (AH). The aim of the study was to investigate arterial elasticity in the elderly AH patient...

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New oral  anticoagulants are  effective for  the  prevention of thromboembolic complications in patients with atrial fibrillation, or after orthopedic surgery. The use  of these drugs may be associated with the  risk of bleeding from the  gastrointestinal tract — a dangerous complication, which can...

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Aim. To study the clinical and diagnostic role of pulse wave time (PWT) in 24-hour blood pressure monitoring (BPM) and its link to elasticity of larger arteries and aorta (carotid-femoral pulse wave velocity, PWVcf; cardioankle vascular index, CAVI) in patients aged over 75 years.Material and method...

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Aim. To study the characteristics of renin profile and parameters of central pulse wave and arterial stiffness in patients with previously untreated arterial hypertension (HT). Material and methods. Patients (n=83;  39 males (47%); age 57.3±7.6 years) with untreated uncomplicated 1-2 degree HT witho...

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