Search Results - Yu. V. Kolobovnikova
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PECULIARITIES OF THE FUNCTIONAL ACTIVITY OF BLOOD EOSINOPHIL GRANULOCYTES IN PULMONARY TUBERCULOSIS
Published 2014-10-01Get full textEosinophils are polyfunctional leukocytes detected in excess in blood and in the focus of granulomatous inflammation in pulmonary TB.The research objective was to evaluate the adhesive properties as well as cytokine-secretory and antibacterial activity of blood eosinophils in pulmonary TB.The resear...
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Study of the immunomodulatory effect of lithium salt gamma-lactone of 2,3-dehydro-L-gulonic acid on healthy and malignant blood cells
Published 2024-01-01Get full textThe aim of this work was to study the immunomodulatory effects of lithium salt gamma-lactone of 2,3-dehydro-Lgulonic acid (LiAc) on healthy blood leukocytes and leukemia cells in vitro.Materials and methods. Peripheral blood lymphocytes and neutrophils obtained from healthy donors, as well as THP-1...
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Subpopulation structure of regulatory Т-cells of blood in patients with multiple drugresistant pulmonary tuberculosis
Published 2011-08-01Get full textSubpopulation structure of regulatory T-cells of peripheral blood in patients with newly diagnosed pulmonary tuberculosis depending on the clinical form of disease and sensitivity of Mycobacterium tuberculosis to anti-tuberculosis drugs have been analyzed in this work. It has been shown that in form...
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Disturbance mechanisms of eosinophils’ and immunocytes’ cooperation in the forming large blood eosinophilias
Published 2006-06-01Get full textData of modern literature and results of own investigations concerning the role of imbalance of immune-regulatory cytokines’ system in the mechanisms of forming severe eosinophilias of blood in pathologic processes of different genesisare analyzed in the article
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Phenotypic features of erythrocytes and activity of erythropoiesis in cardiosurgical patients with various degree of postperfusion hemolysis manifestation
Published 2012-12-01Get full textA study of phenotypic characteristics of erythrocytes and indicators of activity of erythropoiesis in cardiosurgical patients with moderated (40 patients) and expressed (18 patients) hemolysis after coronary artery bypass grafting in conditions of cardiopulmonary bypass was carried out. Before and a...
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The role of polymorphism of genes IL5 (–703) and IL5RA (–80) in formation of blood eosinophilia under pulmonary tuberculosis
Published 2012-08-01Get full textWith attracting contemporary molecular-genetic and immunological research methods, the article analyses etiopathogenetical factors of formation of eosinophilic blood reaction under pulmonary tuberculosis. It has been established that blood eosinophilia under pulmonary tuberculosis is reactive, media...
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Clinicopathological features of colon cancer depending on the dMMR status of the tumor
Published 2024-01-01Get full textAim. To conduct a clinical and morphological assessment of the characteristics of colon cancer depending on the dMMR / pMMR status of the tumor.Materials and methods. A retrospective study included 66 patients with operable colorectal cancer (CRC) (T1-4bN0-2bM1), who were treated at Cancer Research...
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The expression of CCL11/eotaxin, CCR3 receptor and eosinophil peroxidase in tumor tissue in gastric and colon cancers
Published 2018-09-01Get full textThe purpose of the study was to analyze the expression of CCL11/eotaxin, CCR3 receptor to eotaxin and eosinophil peroxidase (EXP) in tumor tissue and its relation to tissue eosinophilia in gastric and colon cancers.Materials and methods. 52 patients with gastric cancer and 55 patients with colon can...
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Clinical and X-ray features of pulmonary tuberculosis with blood eosinophilia
Published 2012-12-01Get full textThe article presents a comparative analysis of clinical and radiological parameters in patients with pulmonary tuberculosis accompanied by eosinophilia and without eosinophilia.The study found that tuberculosis infection combined with eosinophilic reaction of the blood characterized by destructive c...
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Cytotoxic potential of eosinophiles’ granulocytes in patients having eosinophilia syndrome
Published 2006-09-01Get full textIn malignant diseases of blood system and opisthorchiasis (sharp and chronic), significant strain of microbicide mechanisms of eosinophilic row leukocytes causes forming their high cytotoxic potential action of which could be realized concerning not only antigenic structures but also macro-organism...
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Features of immunoregulation in patients with pulmonary tuberculosis with blood eosinophilia
Published 2018-09-01Get full textThe aim of the investigation was to determine the characteristics of the immune response regulation for pulmonary tuberculosis (TB) and to analyze the role of regulatory T cells in the immunopathogenesis of TB with eosinophilia in the blood, depending on the clinical form of the disease and sensitiv...
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Expression of CD80 and HLA-DR molecules on blood monocytes in patients with pulmonary tuberculosis
Published 2021-11-01Get full textWe examined expression pattern of CD80 and HLA-DR pro-inflammatory molecules on the monocytes in patients with pulmonary tuberculosis (TB), depending on the clinical form of the disease and susceptibility of the pathogen to anti-tuberculosis drugs. The study involved forty-five patients with newly d...
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VEGF-and EGF-mediated cooperation of eosinophilic granulocytes and tumor cells in gastric and colon cancer
Published 2019-05-01Get full textAim of the research – to analyze secretion of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) by blood eosinophilic granulocytes in vitro, together with an expression of VEGFR and EGFR in tumor tissue in gastric and colon cancer in association with tissue eosinophilia.Mat...
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The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis
Published 2012-12-01Get full textWith attracting contemporary molecular-genetic and immunological research methods, it has been established that blood eosinophilia under pulmonary tuberculosis is mediated by hypersecretion eotaxin. Susceptibility to the emergence of eosinophilic blood reaction under tubercular infection is associat...
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The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis
Published 2017-01-01Get full textThe article provides an overview of scientific research to explain the mechanisms of inefficient implementation of antigen-specific immune response in patients with tuberculosis infection depending on the clinical form (infiltrative and disseminated pulmonary tuberculosis) and the course (drug-sensi...
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Galectin-1-mediated expression of proteins-regulators of cell cycle and growth factors in gastric cancer
Published 2018-01-01Get full textThe purpose of the study was to analyze the expression of proteins-regulators of the cell cycle (p53 and p21) and receptors for endothelial (VEGFR) and epidermal (EGFR) growth factors depending on the expression of galectin-1 in tumor cells in gastric cancer.Materials and methods. 52 patients with d...
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MECHANISMS OF DISTURBED COOPERATION BETWEEN LYMPHOCYTES AND EOSINOPHILS IN HEMOBLASTOSES COMPLICATED WITH EOSINOPHILIC SYNDROME
Published 2014-07-01Get full textAbstract. Malignant diseases of blood system, associated with an eosinophilic syndrome, are accompanied by altered production of some key cytokines regulating proliferation, differentiation and activation events in the cells of eosinophilic lineage, as detected with ELISA approach. An imbalanced sec...
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Phenotypic profile of blood monocytes and tumor-associated macrophages in relation to the expression of galectins 1 and 3 in colorectal cancer
Published 2025-01-01Get full textAim. To identify the features of the subpopulation composition of blood monocytes and tumor macrophages in relation to the plasma concentration and intratumoral expression of galectins 1 and 3 in patients with colorectal cancer.Materials and methods. A total of 23 patients with colorectal cancer (IC...
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Features of the biochemical parameters of blood and exudates during tubercular exudative pleurisy
Published 2012-06-01Get full textSome biochemical indicators of peripheral blood and pleural fluid (level of the total protein, glucose, lactate dehydrogenase activity) at patients with various variants of tubercular exudative pleurisy (MBT-positive and MBT-negative) for the purpose of definition of possibility of use this indicato...
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Galectin-1 and Galectin-3 expression in colon cancer and its correlation with tumor invasion, differentiation, and metastatic spread
Published 2021-12-01Get full textAim. To study the expression of galectin-1 and galectin-3 in colon cancer and the levels of these proteins in the peripheral blood in relation to the differentiation, invasion, and metastatic dissemination.Materials and Methods. We examined primary tumors and the corresponding peripheral blood sampl...
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