Hakutulokset - Yu. V. Karpenko

The article examines the mechanisms of the heterocyclization reaction using density functional theory (DFT) methods. A quantum-chemical analysis of the starting compounds, transition states, and products was conducted, with energy barriers and key reaction stages identified. Particular attention was...

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The article discusses effective methods for the synthesis of unsymmetrical disulfides, which are important in the development of new bioactive molecules, pharmaceuticals, and materials for bioconjugation and systemic release. The aim of the work is to develop a method for the synthesis of unsymme...

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The relevance of the study of 1,2,4-triazole derivatives with pyrimidine fragment is due to the synthesis of potential broad-spectrum antibacterial drugs, low molecular weight inducers of interferon, and antitumor agents, search for molecular descriptors of their structure, important for establishin...

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Pain represents a primary symptom of numerous diseases and conditions, affecting millions of people worldwide. Effective analgesic medications can alleviate or eliminate pain, thereby enhancing patients’ quality of life and assisting them in resuming normal physical and social activities. However, s...

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Вивчено сорбційну здатність та кінетику осадження магнітокерованого біосорбенту на основі дріжджів S. сerevisiae та наномагнетиту від параметрів процесу його приготування. Отримано оптимальні співвідношення маси клітин дріжджів і маси магнітних міток, та зроблено висновки щодо практичного застосуван...

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From ancient times the people used different poisons as a treatment for diseases of different genesis. To date, almost nothing has changed. One of the main conditions for the development of a new drug is its low toxicity. Literature analysis has shown that 1,2,4-triazole-3-thione derivatives are low...

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, One of the priority measures, which are evaluated in the creation of new effective medicines, is their high selective effect and lack of side effects. A considerable interest is the possibility of combining several structures of heterocycles in one molecule, such as quinoline and furan, which may...

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Most pharmaceutical compounds interact with various molecular compositions in the body, leading to complex biological effects. Furthermore, during biotransformation, they may generate one or more metabolites with potent bioactive properties. Therefore, the development and careful use of new medicati...

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Heterocyclic compounds make a very important branch of organic chemistry, and it has always been an interesting area of study in medical chemistry. They are present in a variety of drugs, vitamins and biologically active compounds. Over two decades, 1,3,4-oxadiazoles have been of interest to chem...

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At the present stage of development of medical chemistry, many basic synthetic approaches to the synthesis of 1,3,4-oxadiazole structures are known, which are focused mainly on the principles of combinatorial chemistry with a wide range of biological activity. The aim of the work was searching, s...

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In the literature, there is insufficient information on the synthesis of compounds in a series of pyrimidine-2-thiol derivatives containing a five-membered nitrogen-containing heterocyclic fragment; at the same time, there are a sufficient number of examples, demonstrating the synthetic and biologic...

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The 1,2,4-triazole nucleus is resistant to metabolism and is an important pharmacophore; it can increase solubility and improve the pharmacokinetic and pharmacodynamic profile of drugs. Domestic scientists pay much attention to the heterocyclic 1,2,4-triazole system. A two-component system comprisin...

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A combination of two rings of 1,2,4-triazole with the formation of new hybrids, bis-1,2,4-triazoles, with various functional groups and pharmacophores may comprise a promising class of the biologically active compounds. Alkaline phosphatases belong to a broad family of enzymes, ectonucleotidases, wh...

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Esterification of carboxylic acids has vast academic applications in organic synthesis and finds industrial uses as well; for instance, reactions involving esterification of monochloroacetic acid with alcohols are widespread in the pharmaceutical industry. Traditionally esterification has been perfo...

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