Search Results - Yu. M. Lopatin

The results of randomized clinical trials comprising SMILE (The Survival of Myocardial Infarction Long term Evaluation) Project were analyzed. Six-week therapy with an ACE inhibitor zofenopril in acute myocardial infarction (AMI) patients resulted in one-year mortality reduction by 29%. Xofenopril w...

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The article is focused on choosing optimal doses and combinations of neuro-humoral modulators in systolic left ventricular dysfunction and heart failure. The results of CHARM-Added, Val-HeFT, RALES, and EPHESUS studies are analyzed, as well as their effect on modern recommendations on chronic heart...

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Antihypertensive effects of an ACE inhibitor perindopril were analyzed. In ASCOT-BPLA Study, blood pressure (BP) level for amlodipine ± perindopril treatment was lower than for atenolol ± bendroflumethiazide treatment (mean difference 2.7/1.9 mm Hg). Maximal BP difference was 5.9/2.4 mm Hg, by Month...

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The article is focused on modern approaches to heart rate reduction, as a new method for stable angina (SA) management. The algorhithm of SA pharmaceutical treatment, by the European Society of Cardiology (2006), is analyzed.

The paper focuses on beta-blocker potential in perioperative period among the patients undergoing non-cardiac surgery. The results of two randomised clinical trials, POISE (2007) and DECREASE (1999-2009), are analysed.

The article describes the results of a randomized, double-blind, placebo-controlled, parallel-group BEAUTIFUL trial. The position of an If inhibitor ivabradine in the current algorithm of antianginal therapy is analyzed

The paper is focused on the results of a randomised clinical trial SHIFT, which started the discussion about the choice of optimal heart rate-lowering therapy in patients with chronic heart failure (CHF). The author summarizes the benefits of adding an If channel inhibitor ivabradine to the standard...

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Results of HOPE trial are analyzed. It is noted, that treatment with angiotensine converting enzyme inhibitor (iACE) ramipril improves the prognosis in high risk cardio-vascular patients. The objectives and study design of ONTARGET/TRANSCEND trials are introduced. Perspectives of joint use of ACE in...

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Author discusses antiatherosclerotic effects of dihydropyridine calcium channel blocker, amlodipine, in patients with coronary artery disease. Results of randomized clinical trials PREVENT (2000), CAPARES (2000), CAMELOT (2004) and ENCORE II (2009) are analyzed.

The article is focused on choosing heart rate-lowering antianginal medications for patients with stable angina. Antianginal therapy algorithm by the European Society of Cardiology (2006) is analyzed.

Eplerenone (Inspra, Pfizer) improves the prognosis of patients with chronic heart failure and heart failure after acute myocardial infarction. Since Russia eplerenone pharmacoeconomics issues rarely discussed, the analysis of the literature on this topic was performed. 2 studies examined effects of...

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Aim. To research the effect of structured telephone support on the self-care in comorbid patients with chronic heart failure (CHF) over 12 months of follow-up.Material and methods. Self-care was assessed using The Self-care of Heart Failure Index (SCHFI, version 6.2) in 130 patients with CHF II-IV f...

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Aim. To perform clinical and pharmaco-economic assessment of long-term therapy with ACE inhibitors perindopril and enalapril in coronary heart disease (CHD) patients after coronary artery bypass graft (CABG) surgery.Material and methods. This prospective, randomized clinical trial included 250 CHD p...

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Aim. To assess the validity and psychometric properties of the Russian version of the Self-Care of Coronary Heart Disease Inventory (SC-CHDI) in patients with chronic coronary syndromes (CCS).Material and methods. The study was performed on 100 patients with stable coronary artery disease, who were...

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Aim. To assess the validity and reliability of the Russian-language version of The SelfCare of Heart Failure Index (SCHFI, version 6.2) in patients with heart failure (HF).Material and methods. The translation of the SCHFI (version 6.2) into Russian was performed according to the Brislin’s model. Th...

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Aim. Validation and evaluation of psychometric parameters of the Russian-language version of the Coronary Artery Disease Education Questionnaire II (CADE-Q II) in patients with chronic coronary syndromes (CCSs).Material and methods. The study involved 303 patients with stable coronary artery disease...

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Aim. To evaluate the dynamics of clinical parameters and cardiac morphology and function in atorvastatin-treated patients with ischemic heart failure (HF), preserved systolic function, and paroxysmal atrial fibrillation (AF).Material and methods. In total, 60 patients with HF, NYHA functional Class...

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Aim. To evaluate the parameters of central aortic pressure in patients with chronic heart failure (CHF) of ischemic aetiology. Material and methods. The study included 89 patients with ischemic CHF, aged from 41 to 73 years (mean age 56,1±0,8 years), and 15 controls, aged 39–56 years (mean age 49,4±...

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Aim. To assess reliability and discriminant validity of the Russian version of European Scale of Self-care in patients with heart failure (HF).Material and methods. European Scale of self-help assessment in CHF was translated in Russian according to Brislin model by three not related translators. Af...

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Aim. This study sought to translate, cross-culturally adapt, and psychometrically validate the Coronary Artery Disease Education Questionnaire II (CADE-Q II) in Russian.Material and methods. Independent translations and back-translations of the CADE-Q II were conducted by bilingual health profession...

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