Search Results - Yu. A. Shelygin
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Standard characteristics of functional state of the rectal obturator muscles obtained from neurophysiological examination
Published 2018-01-01Get full textThe objective was to evaluate standard neurophysiological characteristics of the external anal sphincter and pelvic floor muscles using electromyography interference pattern analysis.Materials and methods. Electromyography was performed in 33 volunteers without complaints of bowel incontinence or bo...
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Potentials of transanal endoscopic surgery at early rectal cancer
Published 2014-10-01Get full textAim of investigation. Improvement of results of organ-preserving treatment of early rectal cancer, and assessment of sensitivity and specificity of transrectal ultrasound investigation (TRUS) at these patients.Material and methods. Overall 14 patients with adenocarcinomas (uT1N0) of high or moderate...
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Organ-preserving treatment of early rectal cancer
Published 2018-08-01Get full textAim of review. To generalize scientific data and to develop modern concept on the issue of diagnosis, staging and treatment of early rectal cancer. Summary. The world-wide issues of early rectal cancer are discussed in the review. Diagnostic methods and staging of the early cancer and premalignant s...
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Familial adenomatosis coli: surgical treatment with cellular transplantation
Published 2012-11-01Get full textAim of investigation. To develop reconstructed mucosa of the rectum for improvement results of surgical treatment of familial adenomatosis polyposis coli (FAP).Material and methods. Overall 27 patients with FAP underwent surgical treatment including colectomy, demucosation of rectum and allogenic tr...
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Efficacy of ileostomy in Crohn's disease of the large intestine with perianal involvement
Published 2011-12-01Get full textAim of investigation. To estimate efficacy of ileostomy in patients with Crohn's disease of the large intestine with perianal involvement.Material and methods. Overall 43 patients with Crohn's disease of the large intestine with perianal involvement who underwent ileostomy in January, 1998...
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Procalcitonin and C-reactive protein - early predictors of low colorectal anastomotic leakage
Published 2018-08-01Get full textAim of investigation. To determine diagnostic value of procalcitonin (PCT) and C-reactive protein (CRP) at anastomotic leakage (AL) following lower anterior resection (LAR) of the rectum. Material and methods. Overall 100 patients underwent surgery for epithelial tumors of rectum in the period 2013-...
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INFLUENCE OF SOMATIC MUTATIONS OF KRAS, NRAS, BRAF AND MICROSATELLITE INSTABILITY STATUS ON SURVIVAL OF COLORECTAL CANCER PATIENTS WITH PERITONAL CARCINO
Published 2020-10-01Get full textPurpose: to evaluate the effect of somatic mutations of the KRAS, NRAS, BRAF genes and the status of microsatellite instability on the overall and disease-free survival of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.Material and Methods. From 2012 to 2018...
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Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli
Published 2013-12-01Get full textAim of investigation. To study pathogenic mechanisms and morphological signs of rectal mucosa reparation after rectal mucosectomy and application of cellbased biotechnologies at surgical treatment of familial adenomatosis coli (FAC).Material and methods. The new method of FAC surgical treatment whic...
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Differential Diagnosis of MutYH-Associated Polyposis from Sporadic Colon Polyps
Published 2019-01-01Get full textAim. In this research, we aim to develop a criterion for differentiating MutYH-associated polyposis from sporadic colon polyps.Materials and methods. A search for mutations in the MutYH gene was carried out using the PCR, electrophoresis and direct sequencing methods among the following groups of pe...
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Large Rearrangements in Genes Responsible for Familial Adenomatous Polyposis, <i>MUTYH</i>-Associated Polyposis and Peutz–Jeghers Syndrome in Russian Patients
Published 2023-06-01Get full textАim: to reveal the rate of large rearrangements in the genes responsible for familial adenomatous polyposis, MUTYH-associated polyposis and Peutz–Jeghers syndrome.Materials and methods. The MLPA method was used for identification of large rearrangements. A total number of 135 patients was included i...
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Pattern of morphological and neurophysiologic changes in women with the syndrome of the descending perineum
Published 2014-07-01Get full textAim of investigation. To determine morphological rating of connective tissue structures of perineum and detect neurophysiologic disorders of pelvic floor in patients with the descending perineum syndrome (DPS).Material and methods. Original study included 39 women with DPS in the age of 21 to 68 yea...
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Long-term results of rectocele surgical treatment
Published 2013-09-01Get full textAim of investigation. Evaluation of quality of life and studying of long-term results of treatment in patients after rectocele surgery.Material and methods. Original study included patients (n=41), operated in State Scientific Center of Coloproctology for rectocele in 2007 to 2011. Age of patients w...
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Parameters for evaluating the main indicators of coloproctological care in the adult population in the subjects of the far Eastern Federal District in 2016–2018
Published 2020-11-01Get full textAim. To work out the unified model for description of coloproctological service at the level of federal district.Material and methods. The study is the summary analysis of data from the annual statistical observation “The Report of the Chief Coloproctologist of the Russian Federal District” in 2016–...
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Differentiation of Lynch syndrome from other forms of non-polyposis colorectal cancer among Russian patients
Published 2014-08-01Get full textAim of investigation. Lynch's syndrome is hereditary syndrome caused by germline mutation in one of reparation genes not coupled bases and causing high risk of colorectal cancer development. At present there are no criteria, allowing to reveal all mutation carriers, and development of new guide...
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Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia on Diagnosis and Treatment of Constipation in Adults
Published 2020-12-01Get full textAim. Current clinical recommendations are intended to supply gastroenterologists, physicians and general practitioners with modern methods for the diagnosis and treatment of constipation.Key points. Constipation is defined as primary (functional) and secondary form, the latter comprising a manifestat...
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Diagnosis and treatment of the irritable bowel syndrome: clinical guidelines of the Russian gastroenterological association and Russian association of coloproctology
Published 2018-08-01Get full textAim of publication. To present recent RGA evidencebased medicine centered guidelines on diagnosis, rational pharmacotherapy and management of irritable bowel syndrome (IBS). Summary. IBS - is a functional bowel disorder is manifested by recurrent abdominal pain that develops at least once per week a...
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Diagnosis and Treatment of Irritable Bowel Syndrome: Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia
Published 2022-01-01Get full textAim. Current clinical recommendations accentuate current methods for the diagnosis and treatment of irritable bowel syndrome (IBS).Key points. IBS is a functional bowel disorder manifested with recurrent, at least weekly, abdominal pain with the following attributes (any two leastwise): link to defe...
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