Search Results - Yu. A. Dyleva

Perivascular adipose tissue surrounds most large blood vessels and plays an important role in vascular homeostasis. Recent studies have shown that perivascular adipose tissue effects vasodilation and vasoconstriction, which indicates that the perivascular adipose tissue regulates tone and diameter o...

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The review is devoted to the description of a number of modern technologies called omixes, including genomics, transcriptome, proteomics, metabolomics, lipidomics and multimarker strategy, whose most important goals is the development of biomarkers for the diagnostics of cardiovascular diseases. The...

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Adiponectin, the most common plasma adipocytokine, plays a crucial metabolic and anti-inflammatory role. With insulin resistance associated with obesity, an increase of adiponectin concentration, which leads to the activation of signaling pathways involved in the regulation of metabolism, occurs. Cu...

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Visceral adipose tissue is an important predictor of cardiovascular diseases, which carry more risk than total fat accumulation. Epicardial fat, a special form of visceral fat deposited around the heart, is considered an important predictor of the risk of cardiovascular disease, taking into account...

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Today, the contribution of mesenchymal stem cells (MSCs) to the mechanism of development of pathologies such as calcification of heart valves and blood vessels is being actively discussed. This is due to the fact that the formation of calcifications in the cardiovascular system (CVS) repeats the pro...

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Adipose tissue dysfunction characterized by a loss of homeostatic functions It is observed in patients with obesity, insulin resistance and diabetes. In case of violation of the physiological properties in adipose tissue, an increased production of cytokines and chemokines occurs with the infiltrati...

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Aim. To compare the incidence of leptin resistance (LR) in patients with acute and chronic coronary artery disease (CAD) and patients with acquired heart defects (AHD).Material and methods. The study included 234 patients: 114 patients with acute myocardial infarction (MI) and 120 patients with chro...

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Aim. To determine the features of expression and secretion of plasminogen activator inhibitor-1 (PAI-1) by subcutaneous, epicardial and perivascular adipocytes depending on the complexity of coronary artery disease (CAD).Material and methods. The study included 86 patients with CAD, including 35 wit...

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Purpose of the study. A comprehensive quantification of ectopic fat depots using modern methods of radiation diagnosis in patients with ischemic heart disease.Patients and methods. The study included 76 patients with a verified diagnosis of ischemic heart disease (IHD). The control group consisted o...

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Aim. To determine the expression of adiponectin, leptin and I interleukin-6 (IL-6) in subcutaneous, epicardial and perivascular adipose tissue, depending on the presence of cardiovascular risk factors.Material and methods. The study included 90 patients with stable coronary artery disease (CAD) who...

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Aim. To study markers of insulin resistance and adipokine status in patients with visceral obesity in dynamics of hospital period of myocardial infarction and to evaluate carbohydrate metabolism changes in a year after the disease. Material and methods. Totally 94 patients studied with myocardial in...

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Aim. To describe ceramide profile of subcutaneous, epicardial, perivascular adipose tissue (SAT, EAT, PVAT, respectively) in patients with cardiovascular diseases (CVD) depending on smoking.Material and methods. Ceramide (CER) profile in the SAT, EAT, PVAT of patients with CVD (30 patients with coro...

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In general population and among diabetic patients, insulin resistance (IR) is regarded as a cardiovascular risk factor. The aim of this study was to assess the dynamics of IR markers among non-diabetic and diabetic (Type 2 diabetes mellitus, DM-2) patients with acute myocardial infarction and ST seg...

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Aim. To evaluate the expression of leptin receptor isoforms in local fat depots in patients with coronary artery disease (CAD) and acquired heart defects (AHDs).Material and methods. The study included 120 patients with CAD. The comparison group consisted of 96 patients with degenerative aortic sten...

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Presence of myocardial infarction in patients with obesity can lead to an uncontrolled increase in proinflammatory cytokines and unfavorable course of the pathological process. Objective: to study the relationship of key inflammatory factors and the development of complications at different terms af...

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Aim. To study the dynamics of procollagen type I carboxy-terminal propeptide (PICP) with an assessment of potential associations with cardiac fibrosis (CF) and diastolic dysfunction (DD) of the left ventricle (LV) during the hospitalization and one year after ST segment elevation myocardial infarcti...

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Aim. To assess the osteogenic potential of mesenchymal stem cells (MSCs) of epicardial adipose tissue (EAT) in patients with stable coronary heart disease based on obtaining gene profiles (osteogenesis markers). Materials and methods. In EAT MSCs, the expression levels of the RUNX2 (RUNX transcripti...

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Aim. To assess the levels of ST2 and NT-proBNP in serum of infarction patients (MI) in dynamics of hospital period and their relation with adaptive and desadaptive variants of myocardium remodeling.Material and methods. Totally, 87 patients (65 men and 22 women) with MI with ST elevation (STEMI), of...

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Aim. To compare the expression of enzymes of the ceramide de novo synthesis pathway in cardiac adipose tissue (AT) and blood vessels of patients with coronary artery disease (CAD) and acquired heart defects.Material and methods. The study included 20 patients with CAD and 18 patients with aortic ste...

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Aim. To assess the changes of biochemical markers in hospitalization, the relationship with the severity of myocardial fibrosis and the epicardial adipose tissue (EAT) thickness one year after myocardial infarction (MI).Material and methods. A total of 88 patients (65 men and 23 women) with MI were...

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