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    High matrix metalloproteinase-2 expression predicts poor prognosis of colon adenocarcinoma and is associated with PD-L1 expression and lymphocyte infiltration

    High matrix metalloproteinase-2 expression predicts poor prognosis of colon adenocarcinoma and is associated with PD-L1 expression and lymphocyte infiltration by Yiyi Xiao, Guangming Li, Yongjie Xie, Bo Shao, Jingpeng Hao, Yanglin Zhu, Dejun Kong, Yafei Qin, Hong Qin, Shaohua Ren, Hongda Wang, Chenglu Sun, Hao Wang

    Published 2025-06-01

    Background Colon adenocarcinoma (COAD) is a prevalent and aggressive malignancy with limited treatment options, particularly for advanced stages. While programmed death-ligand 1 (PD-L1) inhibition, has emerged as an appealing therapeutic approach for COAD, its effectiveness as a monotherapy is hinde...

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