Risultati della ricerca - Yi He
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A Signal On-Off Ratiometric Molecularly Imprinted Electrochemical Sensor Based on MXene/PEI-MWCNTs Signal Amplification for the Detection of Diuron
Pubblicazione 2025-07-01TestoDiuron (DU) is a widely used phenylurea herbicide designed to inhibit weed growth, but its high toxicity and prolonged half-life contribute significantly to environmental contamination. The majority of electrochemical (EC) sensors typically rely on a single response signal for the detection of DU, r...
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A Subtraction Coronary Computed Tomography Angiography Technique to Evaluate In-stent Restenosis
Pubblicazione 2025-07-01TestoObjective: We investigated the clinical value of subtraction coronary computed tomography angiography (sub-CCTA) in double breath-holding mode for assessing in-stent restenosis (ISR). Materials and methods: Records were identified for stent implantation patients who underwent coronary computed tomog...
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Immunometabolic Interactions in Obesity: Implications for Therapeutic Strategies
Pubblicazione 2025-06-01TestoObesity is characterized by excessive fat accumulation that triggers chronic low-grade inflammation and systemic immune dysregulation, significantly increasing the risk of metabolic disorders including insulin resistance, type 2 diabetes, and cardiovascular disease. This review examines the bidirect...
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Current status and trends of wheat genetic transformation studies in China
Pubblicazione 2015-03-01TestoMore than 20 years have passed since the first report on successful genetic transformation of wheat. With the establishment and improvement of transformation platform, great progresses have been made on wheat genetic transformation both on its fundamental and applied studies in China, especially dri...
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Automated Optical Flow Based Registration for Adaptive Optics Scanning Laser Ophthalmoscope
Pubblicazione 2020-01-01TestoThis study presents an automated registration method based on optical flow for an adaptive optics scanning laser ophthalmoscope. The method was designed to align and average images to obtain a higher signal-to-noise ratio image. A correlation based optical flow image registration method, which has l...
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Semaglutide ameliorates diabetes-associated cognitive dysfunction in mouse model of type 2 diabetes
Pubblicazione 2025-01-01 Testo
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Research on the Distribution and Escape Characteristics of Dust at the Blasting Pile in an Open-Pit Mining Area
Pubblicazione 2025-06-01TestoIn open-pit mines, substantial amounts of dust are generated at various stages. Due to the long duration, repeated mechanical disturbance, and large volume of material handled during the shoveling and loading of blasting piles, this stage is recognized as one of the primary contributors to overall d...
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Activation of Adenosine Phosphate Signaling Promotes Antitumor Immunity in Tumor Microenvironment and Facilitate Immunotherapy
Pubblicazione 2025-06-01TestoABSTRACT Adenosine 5′‐triphosphate (ATP) plays a crucial role in intracellular energetic metabolism and functions as a signal transducer in shaping the tumor microenvironment (TME). However, the understanding of the biological functions of adenosine phosphate signaling and its clinical relevance rem...
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Relationship between spatio-temporal evolution of soil pH and geological environment/surface cover in the eastern Nenjiang River Basin of Northeast China during the past 30 years
Pubblicazione 2023-07-01TestoABSTRACT: To illuminate the spatio-temporal variation characteristics and geochemical driving mechanism of soil pH in the Nenjiang River Basin, the National Multi-objective Regional Geochemical Survey data of topsoil, the Second National Soil Survey data and Normalized Difference Vegetation Index (N...
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Protocadherin 7 inhibits cell migration and invasion through E-cadherin in gastric cancer
Pubblicazione 2017-04-01TestoThe protocadherin 7 is a member of the protocadherin family that expressed aberrantly in many types of human cancers. However, its expression, function, and underlying mechanisms are little known in gastric cancer. In this study, we detected protocadherin 7 expression in gastric cancer tissues and n...
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Dual targeting of BCMA and SLAMF7 with the CARtein system: chimeric antigen receptors with intein-mediated splicing elicit specific T cell activation against multiple myeloma
Pubblicazione 2025-07-01TestoIntroductionChimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy against multiple myeloma (MM). However, several barriers continue to limit the overall effectiveness of this approach, such as high production costs, prolonged manufacturing timelines, safety issues, and...
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Elucidating the Mechanism of ShaoMaZhiJing Granules for Treating Tourette Syndrome: A Metabolomics- and Proteomics-Based Study
Pubblicazione 2025-04-01TestoObjective: This study aimed to explore the mechanism of action of ShaoMaZhiJing granules (SMZJ) in the treatment of Tourette syndrome (TS) using metabolomic and proteomic methods. Materials and Methods: Sprague–Dawley rats were divided into five groups: control, model, haloperidol, low-dose SMZJ (SM...
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Adaptive Laboratory Evolution of a Microbial Consortium Enhancing Non-Protein Nitrogen Assimilation for Feed Protein Production
Pubblicazione 2025-06-01TestoThe increasing global demand for protein underscores the necessity for sustainable alternatives to soybean-based animal feed, which poses a challenge to human food security. Thus, the search for sustainable, alternative protein sources is transforming the feed industry in its effort to sustainable o...
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Efficacy and safety of Kunxinning granules in patients with menopausal syndrome: a multicenter, randomized, double-blinded, and placebo-controlled trial
Pubblicazione 2025-07-01TestoBackgroundMenopausal syndrome is a general term for a series of physical and psychological symptoms that women experience during menopause and perimenopause, which can lead to the occurrence of a variety of diseases. Many ingredients in Kunxinning granules have been used clinically to treat menopaus...
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Pseudomonas sp. TK35-L enhances tobacco root development and growth by inducing HRGPnt3 expression in plant lateral root formation
Pubblicazione 2020-10-01TestoRhizosphere colonization is a key requirement for the application of plant growth-promoting rhizobacteria (PGPR) as a biofertilizer. Signaling molecules are often exchanged between PGPR and plants, and genes in plants may respond to the action of PGPR. Here, the luciferase luxAB gene was electrotran...
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Impact of pre-transplant body mass index on outcomes in AML patients aged ≥ 50 years after allogeneic hematopoietic cell transplantation
Pubblicazione 2025-07-01TestoIntroductionThe prognostic significance of body mass index (BMI) in elderly acute myeloid leukemia (AML) patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) remains controversial.MethodsThis retrospective study analyzed 142 AML patients aged ≥50 years receiving allo-HCT (201...
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Quantitative Trait Loci Associated with Micronutrient Concentrations in Two Recombinant Inbred Wheat Lines
Pubblicazione 2014-11-01TestoMicronutrient malnutrition affects over three billion people worldwide, especially women and children in developing countries. Increasing the bioavailable concentrations of essential elements in the edible portions of crops is an effective resolution to address this issue. To determine the genetic f...
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Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence
Pubblicazione 2025-07-01TestoAbstract Diffuse‐type tenosynovial giant cell tumor (D‐TGCT) and localized‐type tenosynovial giant cell tumor (L‐TGCT) share common genomic aberrations and histopathological features, but the former has a more aggressive nature and a higher recurrence rate, leading to worse prognoses for patients. I...
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Genetic Structure and Diversity of Parental Cultivars Involved in China Mainland Sugarcane Breeding Programs as Inferred from DNA Microsatellites
Pubblicazione 2012-11-01TestoTo understand genetic structure and diversity of parental cultivars involved in China Mainland sugarcane breeding programs, 92 elite parents and 4 wild relatives were genotyped with 18 microsatellite DNA markers. The genetic similarity (GS) values among the cultivars ranged from 0.346 to 0.960 with...
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Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement
Pubblicazione 2025-07-01TestoBackgroundMyeloid cells, such as resident microglia (MG), infiltrating monocytes (Mo), macrophages (MΦ), and CNS border-associated macrophages (BAM) in the brain, participate in aged brain injury. Aged microglial replacement is protective against brain injury in aged mice; however, whether/how the m...
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