Search Results - Ye. N. Shirokova
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Intrahepatic Cholestasis in Non-Alcoholic Fatty Liver Disease: Pathogenesis and Role of Ademetionine in Treatment
Published 2023-08-01Get full textAim: to evaluate features of intrahepatic cholestasis (IHC) pathogenesis in non-alcoholic fatty liver disease (NAFLD), as well as role of ademetionine in treatment of this condition.Key statements. NAFLD is the most frequent chronic diffuse liver disease. Increase in proportion of people with excess...
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Treatment response rate and life prognosis at autoimmune liver diseases
Published 2015-10-01Get full textThe aim of review. To carry out comparative analysis of modern studies, to characterize actual modes of treatment and to define prognosis and features of treatment response at various autoimmune liver diseases.Key points. Diagnostics and treatment are the most complex and insufficiently investigated...
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Non-invasive of liver fibrosis diagnostics: the role of serum markers
Published 2015-05-01Get full textAim of review. The prognosis and management approach for chronic liver diseases of any etiology in many respects are determined by stage and extent of fibrosis which reflects activity, spread and duration of liver disease. Aim of current publication was to highlight these issues.Summary. Investigati...
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Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment
Published 2012-09-01Get full textThe aim of review. To generalize new data on diagnostics, pathogenesis and treatment of autoimmune hepatitis (AIH).Original positions. AIH is a chronic inflammatory liver disease which is characterized by destruction of terminal plate by mononuclear infiltrate (interface hepatitis) according to hist...
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Nuclear receptors in regulation of bile acids transport and metabolism
Published 2013-10-01Get full textThe aim of review. Nuclear receptors are ligandactivated transcription factors, involved in regulation of metabolism and transport of bile acids (BA) both under physiological, and cholestatic conditions. Accumulation of BA and other bile components in hepatocytes during cholestatic liver diseases is...
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Noninvasive diagnostic methods of liver fibrosis in patients with primary biliary cirrhosis and primary sclerosing cholangitis: role of indirect serological markers
Published 2016-08-01Get full textAim of investigation. Considering prognostic value and dynamic nature of liver fibrosis in chronic cholestatic diseases: primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), severity assessment by liver biopsy and/or noninvasive methods should be obligatory component of the inve...
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Comparative characteristic of apoptosis of peripheral leukocytes at viral and autoimmune liver diseases
Published 2009-08-01Get full textAim of investigation. To compare a level of apoptosis of peripheral blood leukocytes at chronic hepatites (CH) B, C and autoimmune overlap syndrome (AOS) of autoimmune hepatitis and primary biliary cirrhosis.Material and methods. To study level of apoptosis and pattern of DNA of peripheral blood leu...
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