Søgeresultater - Yanping Zhang
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Antidepressant use and all-cause mortality in depressed individuals: A real-world cohort study.
Udgivet 2025-01-01Få fuldtekst<h4>Background</h4>While antidepressants are effective in alleviating symptoms, their association with mortality remains unclear. This research investigated the link between antidepressant usage and all-cause mortality among depressed patients.<h4>Methods</h4>We performed a r...
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Engineering Methylotrophic Yeasts as Cell Factories for Chemical Production Using Methanol as a Feedstock
Udgivet 2025-08-01Få fuldtekstABSTRACT Methanol, a sustainable and abundant one‐carbon (C1) feedstock, has emerged as a promising raw material for green biomanufacturing, offering a pathway to carbon neutrality. Natural methylotrophic yeasts such as Pichia pastoris (syn. Komagataella phaffii) and Ogataea polymorpha are increasin...
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Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit
Udgivet 2025-07-01Få fuldtekstPurposeTo investigate the distribution characteristics and drug resistance of pathogenic bacteria in bloodstream infections, providing a basis for rational clinical treatment.Patients and methodsRetrospective analysis of 1,282 pathogenic strains isolated from blood cultures in the intensive care uni...
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A safety study of ultra‐high dose rate FLASH radiotherapy in the treatment of superficial skin tumors: study protocol of a phase I trial (ChiCTR2400080935)
Udgivet 2025-06-01Få fuldtekstAbstract Objective Ultra‐high dose rate FLASH radiotherapy (FLASH‐RT) is emerging as a novel technique to improve the normal tissue tolerance by delivering ultra‐high dose rate radiation several orders of magnitude higher than convention radiotherapy. It has been shown in preclinical studies to caus...
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Development and Application of Indirect ELISA for IBDV VP2 Antibodies Detection in Poultry
Udgivet 2025-06-01Få fuldtekstInfectious bursal disease virus (IBDV) is one of the most important immunosuppressive viruses in poultry, causing the global spread of infectious bursal disease (IBD). It poses a significant threat to the healthy development of the poultry industry. Vaccination is an effective approach for controlli...
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Waning immunity, prevailing non-vaccine type ptxP3 and macrolide-resistant strains in the 2024 pertussis outbreak in China: a multicentre cross-sectional descriptive studyResearch...
Udgivet 2025-07-01Få fuldtekstSummary: Background: In the spring and summer of 2024, an unexpected large outbreak of pertussis hit China, with the annual incidence of pertussis (34.03/100,000) more than 12-fold higher than that of 2023 (2.71/100,000). We aimed to assess clinical and molecular epidemiological patterns and unrave...
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Development of an improved reverse genetics system for avian metapneumovirus (aMPV): A novel vaccine vector protects against aMPV and infectious bursal disease virus
Udgivet 2025-05-01Få fuldtekstAvian metapneumovirus (aMPV), a paramyxovirus, causes acute respiratory diseases in turkeys and swollen head syndrome in chickens. This study established a reverse genetics system for aMPV subtype B LN16-A strain based on T7 RNA polymerase. Full-length cDNA of the LN16-A strain was constructed by as...
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A novel live attenuated vaccine candidate protects chickens against subtype B avian metapneumovirus
Udgivet 2024-05-01Få fuldtekstAvian metapneumovirus (aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the dominant epidemic strain in China. We developed an attenuated aMPV subtype B strain by...
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