Search Results - Yanping Han
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Molecular mechanisms and applications of natural transformation in bacteria
Published 2025-06-01Get full textNatural transformation is a process in which bacteria uptake exogenous DNA from the environment during a transient physiological state called competence. The DNA can either autonomously replicate or integrate into the bacterial chromosome through homologous recombination. Natural transformation has...
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Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and health care
Published 2025-07-01Get full textThe terms “inflammatome” (holistic inflammation networks) and “inflammatomics” (a novel omics field) were proposed to decode dysbiosis-driven chronic inflammation and its disease links. Inflammatomics explores microbiota–immune crosstalk, particularly innate immune interactions, revealing how dysreg...
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Retracing the path of evolution: polymorphisms of aspA codon 363 shape the fitness of Yersinia pestis
Published 2025-12-01Get full textYersinia pestis, the etiologic agent of plague, is a genetically monomorphic pathogen. By screening 1085 published Y. pestis genomes, we identified an unusual mutation hotspot within codon 363 of the aspartate ammonia-lyase gene aspA with at least six alleles in the population. Our investigation del...
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