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    Total neoadjuvant therapy integrating long-course radiotherapy with trifluridine/tipiracil for locally advanced rectal cancer: a single-arm, multicenter phase 2 trialResearch in context

    Total neoadjuvant therapy integrating long-course radiotherapy with trifluridine/tipiracil for locally advanced rectal cancer: a single-arm, multicenter phase 2 trialResearch in co... by Xue Dou, Lina Zhao, Zhenyu Ma, Lichun Wei, Xin Jiang, Yi Ding, Shichang Sun, Yanlai Sun, Minghuan Li, Rui Feng, Kunli Zhu, Fang Shi, Kai Liu, Minghao Li, Yongsheng Gao, Peng Su, Shanshan Li, Jinming Yu, Jinbo Yue

    Published 2025-07-01

    Summary: Background: Total neoadjuvant therapy (TNT) is recommended for locally advanced rectal cancer (LARC) with high-risk factors. The objective of this multi-center phase 2 study is to evaluate the impact of a newly designed TNT consist of TAS-102 concurrent with long-course radiotherapy follow...

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