Ngā hua rapu - Yang Sun

Recently developed base editing (BE), prime editing (PE), and click editing (CE) technologies enable precise and efficient genome editing with minimal risk of double-strand breaks and associated toxicity. However, their effectiveness in correcting real disease-causing mutations has not been systemat...

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Kawasaki disease (KD) is a form of vasculitis that affects primarily children and can lead to severe cardiovascular complications. Because current treatment options are often ineffective for some patients, new therapeutic strategies are needed. Cryptotanshinone (CTS), a compound derived from Salvia...

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Cancer is the leading cause of morbidity and mortality worldwide and is an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally and increasing numbers of natural products are approved for clinical studies invo...

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IntroductionIn educational settings, the role of neuroplasticity in shaping cognitive development has gained increasing attention. Traditional pedagogical models often fail to capture the dynamic neural adaptations that underlie effective learning. To bridge this gap, we propose a novel approach tha...

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Brugada syndrome is a rare inherited heart disease characterized by ventricular arrhythmias and characteristic ST segment elevation, which increases the risk of sudden death. Studies have shown that the pathogenesis of this disease involves a variety of gene mutations, including abnormal functions o...

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Abstract The study of strongly correlated electron systems remains a fundamental challenge in condensed matter physics, particularly in two-dimensional (2D) systems hosting various exotic phases of matter including quantum spin liquids, unconventional superconductivity, and topological orders. Altho...

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As natural bioactive macromolecules, plant polysaccharides exhibit significant potential in tumor therapy through the regulation of the tumor microenvironment (TME). This review systematically synthesizes 88 studies retrieved from PubMed and CNKI databases (2015–2025), demonstrating that plant polys...

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Chitin deacetylase (CDA) plays a pivotal role in converting chitin to chitosan, yet industrial applications remain constrained by low enzymatic activity, instability under process conditions, and insufficient understanding of metalloenzyme activation mechanisms. Addressing these challenges, we condu...

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Fiber reinforced ceramic matrix composites (FRCMCs) are the preferred materials for safety critical components in the fields of aerospace, nuclear engineering, and transportation, with broad market and application prospects. However, due to the characteristics of multiphase, heterogeneity, and aniso...

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<h4>Background</h4>Antihypertensive treatment mitigates the progression of chronic kidney disease. Here, we comparatively assessed the effects of antihypertensive agents in normotensive and hypertensive diabetic patients with microalbuminuric kidney disease.<h4>Methods</h4>ME...

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<b>Background</b>: Cell membrane proteins play crucial roles in signal transduction and nutrient transport. Many membrane proteins are reportedly overexpressed in cancer cells, which is closely related to cancer progression. The targeted degradation of these membrane proteins has been de...

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ABSTRACT Background Breast cancer was the second most common cancer and the fifth leading cause of cancer deaths among women in China, with increasing trends. Evaluating breast cancer trends and predicting future burdens can inform prevention strategies. This study aimed to analyze the trends in fem...

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Acid phosphatase (ACPase) is an essential industrial enzyme, but its production via recombinant bacterial fermentation is often limited by insufficient dissolved oxygen control. This study optimized the aerobic fermentation of the ACPase-producing recombinant bacterium <i>Bacillus subtilis<...

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A coding ruler is a device that marks position information in the fordigital signals, and a code reader is a device that decodes the signals on the coding ruler and converts them into digital signals. The code reader and encoder ruler are key devices in ensuring the positioning accuracy of coke oven...

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The <i>Molecules</i> journal retracts the article titled “Resveratrol Inhibits the Migration and Metastasis of MDA-MB-231 Human Breast Cancer by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition” [...]

Methylation of the N6 position of adenine, termed N6-methyladenine, protects DNA from restriction endonucleases via the host-specific restriction-modification system. N6-methyladenine was discovered and has been well studied in bacteria. N6-adenine-specific DNA methyltransferase (N6AMT) is the main...

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<b>Aims:</b>This study aimed to identify the prognostic value of tumor invasion distance (TID) based on MRI findings in cervical-cancer (CC) patients treated with radiotherapy (RT). <b>Methods</b>: A total of 218 CC patients diagnosed at Fujian Cancer Hospital from December 2...

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Excessive consumption of acetaminophen (APAP) has emerged as the primary culprit behind drug-induced liver injury (DILI), with N-acetylcysteine serving as the principal antidote. However, use of N-acetylcysteine is limited to the early stages of APAP-induced DILI and may cause adverse side effects....

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BackgroundIHF is a major chronic disease that seriously threatens human health. Qi deficiency and blood stasis syndrome (QDBS), Yang deficiency with blood stasis syndrome (YDBS) and Yang deficiency and blood stasis with fluid retention syndrome (YDBSFR) are the basic syndromes of IHF in Chinese medi...

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