Search Results - Yan Qu
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Causal relationship between varicose veins and hydrocele: A bidirectional two-sample Mendelian randomization study
Published 2025-05-01Get full textObjective: This study aimed to investigate the causal relationship between varicose veins and hydroceles. Methods: Genetic data for varicose veins and hydroceles were extracted from a Genome-Wide Association Study (GWAS). A total of 22,037 cases of varicose veins and 2634 cases of hydroceles were in...
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Gait dynamics and brain function abnormalities in Parkinson’s disease with freezing of gait: a clinical study using resting-state fMRI and wearable devices
Published 2025-07-01Get full textIntroductionParkinson’s disease (PD)-associated freezing of gait (FoG) (PDFoG) refers to episodes where patients feel the urge to move but experience temporary immobility or markedly shortened steps. This leads to frequent falls and, eventually, the loss of walking ability, severely affecting patien...
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Nitrogen (N) metabolism related enzyme activities, cell ultrastructure and nutrient contents as affected by N level and barley genotype
Published 2017-01-01Get full textDevelopment of the new crop cultivars with high yield under low nitrogen (N) input is a fundamental approach to enhance agricultural sustainability, which is dependent on the exploitation of the elite germplasm. In the present study, four barley genotypes (two Tibetan wild and two cultivated), diffe...
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A high-quality genome of Actinidia eriantha provides new insight into ascorbic acid regulation
Published 2023-11-01Get full textActinidia eriantha is one of the species of kiwifruit with a particularly high ascorbic acid (AsA) content. However, the molecular mechanism driving AsA richness in fruit remains unclear. In order to reveal the molecular mechanism of AsA richness in A. eriantha, this study constructed a regulatory n...
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Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy
Published 2025-07-01Get full textBackground The pro-inflammatory cytokine, interleukin-18 (IL-18), plays an instrumental role in bolstering anti-tumor immunity. However, the therapeutic application of IL-18 has been limited due to its susceptibility to neutralization by IL-18 binding protein (IL-18BP), short in vivo half-life, and...
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