Search Results - Xinwei Hu

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    Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides

    Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides by Xinwei Hu, Chengwei Zheng, Xiaotong Song, Balati Hasimujiang, Mu Chen, Zhixiong Ruan

    Published 2025-07-01

    Abstract Dehydroalanine (Dha), a readily introducible non‐canonical amino acid, is widely used for protein post‐translational modification (PTM) and site‐specific labeling of peptides and proteins. Despite its growing applications in biological systems, the precise modification of unnatural amino ac...

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    Manganese suppresses tumor growth through hyper-activating IRE1α

    Manganese suppresses tumor growth through hyper-activating IRE1α by Ruoxi Shi, Ming Wang, Si Chen, Xinwei Hu, Xudong Zhao, Shixin Zhou, Congli Fan, Zihan Zhou, Likun Wang

    Published 2025-08-01

    Summary: IRE1α and its downstream XBP1 signal is the most conserved unfolded protein response pathway that cells utilize to combat endoplasmic reticulum stress, also known to be utilized by tumor cells to adapt to harsh environment, leading to tumor progression. Several inhibitors against IRE1α have...

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