Search Results - Xinwei Han
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Targeting interlukin-6 to relieve immunosuppression in tumor microenvironment
Published 2017-06-01Get full textImmunotolerance is one of the hallmarks of malignant tumors. Tumor cells escape from host immune surveillance through various mechanisms resulting in tumor progression and therapeutic resistance. Interlukin-6 is a proinflammatory cytokine involved in many physiological and pathological processes by...
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3.0-T closed MR-guided microwave ablation for HCC located under the hepatic dome: a single-center experience
Published 2022-12-01Get full textPurpose To analyze the clinical safety and efficacy of 3.0-T closed MR-guided microwave ablation (MWA) for the treatment of HCC located under the hepatic dome.Methods From May 2018 to October 2020, 49 patients with 74 HCCs located under the hepatic dome underwent MWA using 3.0-T closed MR guidance....
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Enhanced Cerenkov radiation induced photodynamic therapy based on GSH-responsive biomimetic nanoplatform to trigger immunogenic cell death for tumor immunotherapy
Published 2025-08-01Get full textCerenkov radiation (CR) can serve as a source of internal light to overcome the limited tissue penetration of external light in conventional photodynamic therapy (PDT). However, insufficient luminescence intensity hinders the clinical application of CR-PDT. Here, we developed a glutathione-responsiv...
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Effect of different combinations of serum antimüllerian hormone levels and body mass index on pregnancy outcomes in women with polycystic ovary syndromeAJOG Global Reports at a Gla...
Published 2025-05-01Get full textBACKGROUND: Both antimüllerian hormone and body mass index are associated with the pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization. OBJECTIVE: This study aimed to explore the effect of different combinations of antimüllerian hormone and body mass index on...
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老年急性卒中患者医院感染预测模型的构建与验证(Construction and Validation of a Prediction Model for Nosocomial Infection in Elderly Patients with Acute Stroke)
Published 2025-07-01Get full text目的 探讨老年急性卒中患者医院感染的危险因素，建立预测模型并进行评价。 方法 回顾性选取2019年6月—2021年12月首都医科大学附属北京天坛医院神经内科住院的老年急性卒中患者作为研究对象。根据患者是否发生医院感染分为感染组和未感染组。按7∶3的比例将数据集分为训练集和测试集，训练集用来建立模型，测试集用来评估模型性能。在训练集中进行单因素和多因素分析，筛选影响因素并构建列线图预测模型。通过Hosmer-Lemeshow拟合优度检验、绘制校准曲线以及ROC曲线分析和决策曲线分析（decision curve analysis，DCA）评估模型预测能力的准确性、区分度和临床实用性。 结果...
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THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer
Published 2024-12-01Get full textAbstract Cancer-associated fibroblasts (CAFs) exert multiple tumor-promoting functions and are key contributors to drug resistance. The mechanisms by which specific subsets of CAFs facilitate oxaliplatin resistance in colorectal cancer (CRC) have not been fully explored. This study found that THBS2...
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