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    Interpretable protein-DNA interactions captured by structure-sequence optimization

    Interpretable protein-DNA interactions captured by structure-sequence optimization by Yafan Zhang, Irene Silvernail, Zhuyang Lin, Xingcheng Lin

    Published 2025-07-01

    Sequence-specific DNA recognition underlies essential processes in gene regulation, yet methods for simultaneous predictions of genomic DNA recognition sites and their binding affinity remain lacking. Here, we present the Interpretable protein-DNA Energy Associative (IDEA) model, a residue-level, in...

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