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    Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration

    Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration par Heran Wang, Xiaodong Liu, Xingzhi Jing, Bofei Zhang, Xin Liu, Xiaoyang Liu, Fei Jia, Cheng Su, Wenchao Wang, Xingang Cui

    Publié 2025-09-01

    Background: Intervertebral disc degeneration (IDD) is a major cause of low back pain, with cartilaginous endplate (CEP) degeneration playing a critical role. While Yes-associated protein (YAP) and its involvement in CEP degeneration and ferroptosis remain unclear. This study aimed to investigate the...

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