Search Results - Xiayan Chu

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    Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity

    Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity by Yanyan Deng, Leizhi Xu, Zhengtao Jiang, Lin Chen, Guanghao Zhu, Chuting Xu, Xiayan Chu, Lixin Wang, Xiaoting Niu, Ling Chen, Zhangping Xiao, Jing Hu, Guangbo Ge

    Published 2025-09-01

    Cisplatin-induced kidney injury (CIKI) is a major adverse effect of this widely used chemotherapy agent. Targeting key events involved in CIKI, such as inflammation, apoptosis, mitochondrial dysfunction and oxidative stress, holds potential for mitigating CIKI and improving patient outcomes. Herein,...

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