Søgeresultater - Xiaoqing Zhang
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Potential mechanisms of action of Jiao'ai decoction in the treatment of premature ovarian failure: Integrated molecular pathway, gut flora, and untargeted metabolism
Udgivet 2025-07-01Få fuldtekstObjective: To explore the pharmacological effects and molecular mechanisms of a Jiao'ai decoction (JAD) in treating premature ovarian failure. Specifically, we evaluated the receptor for advanced glycation end (RAGE) products pathway, metabolic disorders, and intestinal flora dysbiosis. Methods...
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Altering the bacterial community: sour soup decreased CO2 production and improved the fermentation quality of Broussonetia papyrifera, Tritriale and mixed silages
Udgivet 2025-06-01Få fuldtekstIntroductionCarbon dioxide (CO2) generated during the ensiling process is a source of greenhouse gas emissions and a reason for the loss of nutrients during ensiling.MethodsBroussonetia papyrifera (B), Tritriale (T) and their mixtures (B7T3, B5T5 and B3T7) were ensiled with sour soup (S) and Lactoba...
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Nettle supplementation improves antioxidant status and modulates inflammatory response by altering lysophosphatidylcholines and enterolactone metabolism in dairy cows
Udgivet 2025-06-01Få fuldtekstNettle is not only a nutrient-rich forage but also possesses the potential to act as a nutritional and physiological regulator. This study investigated the effects of supplementing nettle hay into the total mixed rations (TMR) on milk yield, milk composition, antioxidant capacity, immune function, a...
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Interplay between MAPK signaling pathway and autophagy in skin aging: mechanistic insights and therapeutic implications
Udgivet 2025-06-01Få fuldtekstSkin aging manifests as structural degradation, functional decline, and heightened disease susceptibility. Central to this process is the overactivation of the mitogen-activated protein kinase (MAPK) signaling pathway triggered by reactive oxygen species (ROS). Autophagy, a lysosomal degradation mec...
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Uncovering common disease mechanisms and critical biomarkers in Crohn's disease with concurrent psoriasis and exploring potential therapeutic agents.
Udgivet 2025-01-01Få fuldtekst<h4>Introduction</h4>Research findings show a substantial correlation between Crohn's disease and psoriasis. However, the exact cause or pathogenesis of the concurrent manifestations of these two conditions in the same individuals remains uncertain. This research aimed to scrutinize...
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Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period
Udgivet 2025-07-01Få fuldtekstBackground and AimsClassification system of tacrolimus elimination and its clinical significance has not been well described in liver transplantation. This study aimed to present a novel tacrolimus clearance clinical-FIS (Fast-Intermediate-Slow) classification and its gene prediction system.MethodsP...
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A global perspective on autoinducer-2-mediated cell communication in prokaryotes
Udgivet 2025-07-01Få fuldtekstSummary: Animal communication within a community is essential for their survival and reproduction. This phenomenon is not restricted to animals but is also prevalent in prokaryotes, which employ quorum sensing (QS) mechanisms for communication and behavior. Despite their importance, cell-cell commun...
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Mcl-1 suppresses abasic site repair following bile acid–induced hepatic cellular DNA damage
Udgivet 2017-07-01Få fuldtekstIn cholestasis, increases in bile acid levels result in the generation of reactive oxygen species and the induction of DNA damage and mutation. It is believed that bile acid accumulation is associated with liver tumorigenesis. However, the mechanism that underpins this phenomenon remains to be eluci...
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Enhancing alfalfa and sorghum silage quality using agricultural wastes: fermentation dynamics, microbial communities, and functional insights
Udgivet 2025-05-01Få fuldtekstAbstract At present, there are many researches on the nutritional quality and fermentation quality of forage silage by adding distillers’ grain and fruit residue, but few researches on the succession and function prediction of microbiotic community. In this study, the potential of Moutai distillers&...
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