Search Results - Xiaoping Yang
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Patient-derived xenograft models: Current status, challenges, and innovations in cancer research
Published 2025-09-01Get full textDespite advancing therapeutic treatments, cancer remains the leading cause of death worldwide, with most of its patients developing drug resistance and recurrence after initial treatment. Therefore, incorporating preclinical models that mimic human cancer biology and drug responses is essential for...
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Human Muscle-Derived Vascular Stem Cells Can Support Hematopoietic Stem/Progenitor Cells In Vitro
Published 2025-01-01Get full textConclusion: In summary, CD146+ PCs and MECs from human skeletal muscle, like human BM-MSCs, have hematopoietic support capacity in vitro.
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FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway
Published 2025-07-01Get full textThe pathogenesis and chemoresistance mechanisms of colon cancer (CC) are still unclear. Here, we find that a long non-coding RNA (lncRNA), FEZ family zinc finger 1-antisense RNA 1 (FEZF1-AS1), is highly expressed in CC, which may be caused by the amplification mutation of FEZF1-AS1 at the gene level...
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Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and exper...
Published 2025-08-01Get full textIntroductionDiabetic nephropathy (DN) is a serious complication of diabetes with limited therapeutic options. Although Huangkui capsule (HKC) and finerenone individually show potential in DN management, their combined mechanism remains unclear. This study aimed to explore the therapeutic effects and...
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Construction of time series prediction and dynamic evaluation model for environmental factors in pregnant sow houses in winter
Published 2025-12-01Get full textWith the expansion of large-scale livestock farming, effective monitoring and control of the pigpen environment have become essential for enhancing efficiency and ensuring animal health. However, the precise control of multiple environmental factors remains a significant challenge. This paper propos...
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Effect of Lactobacillus plantarum 1243 fermentation on quality properties and metabolome of Aronia melanocarpa (Michx.) elliott juice
Published 2025-07-01Get full textAronia melanocarpa (Michx.) Elliott is rich in bioactive compounds, but its poor sensory properties limit its acceptance and further utilization. This study examined Lactobacillus plantarum 1243 fermentation impact on fermented A. melanocarpa juice (FAJ)’s quality properties, flavor profile, and met...
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Adaptive hydrogel loaded with pre-coordinated stem cells for enhanced osteoarthritis therapy
Published 2025-09-01Get full textOsteoarthritis (OA) is a prevalent chronic joint disease with no currently available cure. Despite the promise of mesenchymal stromal cells (MSCs) in promoting OA management, direct intra-articular administration of MSCs faces several critical challenges, including rapid cell clearance from the join...
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