Search Results - Xiaoli Fan
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Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1/FGFR4 signaling
Published 2017-07-01Get full textOvarian cancer is the most lethal gynecologic malignancy, due to its high propensity for metastasis. Cancer-associated fibroblasts, as the dominant component of tumor microenvironment, are crucial for tumor progression. However, the mechanisms underlying the regulation of ovarian cancer cells by can...
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Strong Tough Hydrogel with Regional Programmable Mechanical Properties via Universal Physical Directional Anneal‐Casting Strategy for Bioengineering
Published 2025-07-01Get full textEngineering tissue‐like hydrogels with tailored mechanical properties and matching water contents is essential for biomimetic organ platforms in both ex vivo and in vivo biomedical applications. Achieving this goal is particularly challenging due to the need for a green, straightforward, and univers...
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Genetic dissection and validation of a major QTL for grain weight on chromosome 3B in bread wheat (Triticum aestivum L.)
Published 2024-01-01Get full textGrain weight is one of the key components of wheat (Triticum aestivum L.) yield. Genetic manipulation of grain weight is an efficient approach for improving yield potential in breeding programs. A recombinant inbred line (RIL) population derived from a cross between W7268 and Chuanyu 12 (CY12) was e...
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Liver‐Secreted Extracellular Vesicles Promote Cirrhosis‐Associated Skeletal Muscle Injury Through mtDNA‐cGAS/STING Axis
Published 2025-03-01Get full textAbstract Skeletal muscle atrophy (sarcopenia) is a serious complication of liver cirrhosis, and chronic muscle inflammation plays a pivotal role in its pathologenesis. However, the detailed mechanism through which injured liver tissues mediate skeletal muscle inflammatory injury remains elusive. Her...
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