Search Results - Xiaojing Li
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TBX21 knockdown attenuates neuroinflammation induced by intracerebral hemorrhage via the SIRT1-WDR5-H3K4me3 axis
Published 2025-09-01Get full textNeuroinflammation is a key contributor to the development of secondary brain injury (SBI) following intracerebral hemorrhage (ICH). This study aimed to elucidate the role and underlying mechanisms of T-box transcription factor 21 (TBX21), a known regulator of type I inflammatory responses, in ICH-in...
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A Model‐Independent Strategy for the Targeted Observation Analysis and Its Application in ENSO Prediction
Published 2025-07-01Get full textAbstract The model‐dependency has been a challenging issue for traditional data assimilation‐based targeted observational method. This study developed a new strategy to address this challenge using multiple‐model prediction ensemble. It was found that while the ensemble size reaches a sufficiently l...
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Selenoprotein S ablation-mediated pyroptosis contributes to liver damage resulting from selenium deficiency in chickens
Published 2025-08-01Get full textSelenium is an essential trace element for the synthesis of selenocysteine. Selenoprotein S (SELS) acts as a carrier protein for selenium and exhibits anti-inflammatory properties. However, the role of the SELS in selenium deficiency remains unclear. This study aimed to investigate the role of SELS...
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Spatial and temporal evolution characteristics of apple carbon emissions in China, 1991–2020
Published 2025-05-01Get full textAbstract Articulating the spatial and temporal features of apple carbon emissions in China across different years and areas is critical for developing an appropriate and acceptable apple carbon reduction program. This paper builds a provincial-level database (1991–2020) of apple carbon emissions in...
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Interaction of blood-entry components, network pharmacology and transcriptomics to elucidate the mechanism of Wentong plaster in treating primary dysmenorrhea
Published 2025-07-01Get full textIntroductionPrimary dysmenorrhea (PD) is characterized by pain during the menstrual cycle, affects women's health. Our group developed a traditional Chinese medicine plaster (Wentong plaster, WTT) for the treatment of PD. However, the underlying mechanisms have not yet been elucidated.MethodsIn...
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Distribution characteristics of bacterial communities in central air-conditioning ventilation systems of a Grade 3A hospital in Shanghai based on 16S rRNA sequencing
Published 2025-06-01Get full textBackgroundA diverse cohort of patients and susceptible individuals congregate in healthcare facilities, where exposure to pathogenic microorganisms associated with respiratory infectious diseases constitutes a significant risk factor for cross-infection. Central air-conditioning ventilation systems...
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Limosilactobacillus reuteri HM108 alleviates obesity in rats fed a high-fat diet by modulating the gut microbiota, metabolites, and inhibiting the JAK-STAT signalling pathway
Published 2025-06-01Get full textIntroductionObesity is a globally prevalent metabolic disease, and high-calorie diets are major contributors to its development. Probiotic interventions can modulate the gut flora and alleviate systemic and low-grade inflammation, making them potential in-terventions for alleviating metabolic syndro...
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Global Burden of Dental Caries from 1990 to 2021 and Future Projections
Published 2025-10-01Get full textObjective: To characterise the burdens, trends and risk factors of untreated caries in permanent and deciduous teeth from 1990 to 2021 worldwide. Methods: We extracted data on the incidence, prevalence, and years lived with disability (YLDs) due to dental caries from the Global Burden of Diseases St...
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Antioxidant activity and metabolic profile changes in Poria cocos fermented by breast-milk-derived Limosilactobacillus reuteri HM-R28
Published 2025-06-01Get full textIntroductionThe fermentation of lactic acid bacteria can alter the nutraceutical and functional efficacy of food and medicinal products, particularly when involving bioactive compounds similar to those in Poria cocos (P. cocos), which include polysaccharides and triterpenoids. In this study, we used...
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