Search Results - V. V. Klimov

A 5-year clinical observation of 40 children with frequent respiratory infections and otorhinolaryngologic disorders at the age of from 6 months to 5 years was performed in order to assess clinical and immunological efficacy of modern mucosal vaccine. The tested medicine was shown to significantly d...

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Functional activity of gdТ-cells in atopic dermatitis (AD) in dependence on the disease stage and concomitant pathology character was studied. We investigated 86 patients: 54 women and 32 men aged 17—50 years. AD patients revealed significant insufficiency of the cell immunity, the most marked of th...

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The review focuses on allergen-specific immunotherapy (AIT), a treatment method for atopic diseases, including allergic rhinitis. The theoretical and practical basics, development prospects, indications and contraindications to AIT, peculiarities of AIT execution in allergic rhinitis, and tolerogeni...

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61 people suffering from persistent allergic rhinitis and asthma accompanying food allergies were studied using case histories, the NHANES questionnaire, polyspecific serum levels, allergen-specific IgE, IL4, IFNg and IL10 assays, and allergy skin tests. Four different endotypes have been identified...

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This article provides a review of the phenomenon of entopy or local atopy from the viewpoint of allergic phenotypes and endotypes. A clinical form of the entopy endotype is local allergic rhinitis, which is still a fertile area for research. The exact mechanisms in the breakdown of allergen toleranc...

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Immune cells and molecules, as well as synaptic transmission molecules play a regulatory role in the communication pathways of the entire body when it is necessary to engage all body resources in the fight against infections or tumor cells wherever they appear. In potential allergy, the neuroimmune...

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Local allergic rhinitis is a new atopic disease recognized in modern allergy and rhinology. Its clinical symptoms are currently well described and compared with conventional allergic rhinitis, however, diagnostic and therapeutic protocols, including antigen-specific immunotherapy (ASIT), should be s...

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To study CD1a+ Langerhans cells and their extensions in epidermis and values of IL-4, IL-10, IL-17 and IFN-g in cell-free skin exudate there have been examined 40 patients of atopic dermatitis depending on phase pathological process. There have been found an increase in both CD1a+ dendritic extensio...

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There have been defined IL-4, IL-10, IL-17 and IFN-γ in cell-free skin exudate in 90 patients of atopic dermatitis depending on spread of dermal pathological process. There been found that variations of each cytokine had different features and reflected different parts of immunopathogenesis of the d...

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Over the last decade the role of innate immunity has been known to be crucial for the activation of adaptive immune system. The main triggers that upregulate reactions of innate immunity are small exogenous molecules with conserved motifs, molecular patterns. The article discusses a variety of possi...

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The role of transforming growth factor β (TGF-β) in atopic dermatitis pathogenesis is discussed basing on the analysis of existing data of cellular and molecular mechanisms of allergic inflammation. Up-to date data of the main T-helper (T-h) lymphocyte subpopulations including Tx1, Tx2, Tx3 has been...

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Local allergic rhinitis, a new endotype of allergic rhinitis discerned by researchers of the Spanish Allergy School, is now in the focus of interest of international allergological community. A special feature of local allergic rhinitis, which, being similar to conventional signs of allergic rhiniti...

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Metabolic syndrome (MS) is a serious medical and social problem due to its high prevalence, lack of common approaches to diagnosis and treatment. Prevention of food dysadaptation reactions and the studies of control mechanisms of immune tolerance to food antigens is of special scientific interest, t...

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The main stages of vital way, scientific and educational activities of outstanding Tomsk scientist, academician of the Russian of Medical Sciences and academician of the Ukrainian Academy of Ecological Sciences have been presented. Nikolai Vladimirovich Vasilyev was the head of Tomsk School of immun...

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Autistic spectrum disorders (ASD) affect about one in every 59 children. It is noteworthy that patients with ASD are more likely to have other comorbidities than the general population. Undoubtedly, they may aggravate clinical course of the underlying disease or affect the diagnostics. The aim of th...

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The review considers the molecular structure of inflammasomes, routes of inflammasome activation, appropriate downstream effects, and their association with autoinflammatory, autoimmune, neurodegenerative, and allergic diseases and malignancies with a focus on the involvement of the skin in these pa...

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The lecture considers a place of food allergy in the profile of allergic and, in particular, atopic diseases and its features, distinguishing this pathology from all other allergies. Three classes of food allergens are characterized, and sensitization to them involving cells and regulatory molecules...

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