Search Results - V. S. Kosorukov
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Using short tandem repeat profiling to validate cell lines in biobanks
Published 2022-12-01Get full textAim. To approve the COrDIS kit (Gordiz, Russia) for the authenticity of cell lines from the Bioresource Collection of the N.N. Blokhin National Medical Research Center of Oncology by the short tandem repeat (STR) profiling.Material and methods. The chosen method proved to be a reliable and reproduci...
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Tafalgin is a Russian innovative tetrapeptide pharmaceutical for subcutaneous injection: review of the results of phase I and II clinical trials
Published 2022-08-01Get full textIntroduction. pain syndrome significantly affects quality of life and daily activities of patients with cancer, especially at terminal stages of the disease. Opioid analgesics are considered the “gold standard” of therapy, but their use is associated with bureaucratic difficulties, as well as risk o...
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Bioresource collections: algorithms for development and functioning; basic and applied significance
Published 2023-12-01Get full textBioresource collection of the N. N. Blokhin National Medical Research Center of Oncology is a unique structured biobank that combines different types of primary and subsidiary samples and ensures its comprehensive characterization, including both generally accepted indicators and specific types of r...
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A Panel of Cultures of Cancer and Normal Lung Cells with a Characterized Expression of PD-L1 to Search and Development of the Target Modifiers of Immunotherapy
Published 2024-11-01Get full textBackground. The search for effective combinations of immune checkpoint inhibitors with common cytostatics, targeted cancer drugs and other treatments is a modern trend to improve the effectiveness of immunotherapy.Purpose. Development of a panel of lung cancer cell cultures and cells of normal lung ti...
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Association of the Estrogen Receptors Beta Expression with the Ki-67 Proliferative Index in Breast Cancer
Published 2023-07-01Get full textBackground. Estrogen receptors beta (ERβ) are an important biological regulator and target of antiestrogens, however, unlike estrogen receptors alpha (ERɑ), their significance in the prognosis and treatment of breast cancer remains unclear. Purpose. Evaluation of the ERβ prognostic value in the comp...
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Expression of the cytoskeletal proteins – cytokeratins and beta-III tubulin in human melanoma cell lines from the collection of N. N. Blokhin National Medical Research Center of On...
Published 2023-10-01Get full textIntroduction. Despite advances in the treatment of melanoma, the results of therapy cannot be considered satisfactory, and the search for new drugs and effective combinations of medicine continues. The drugs are being developed aimed at reducing the metastatic tumor potential – migrastatics. The tar...
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Molecular characteristics of non-small cell lung cancer tissue based on quantitative indicators of progesterone receptors expression
Published 2024-04-01Get full textBackground. Progesterone receptors (PR) are regulators of cell proliferation and therefore can be considered as an aim for targeted medications in the treatment of oncological diseases. At the same time, a quantitative assessment of PR expression in the tissue of non-small cell lung cancer (NSCLC),...
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Characterization of Non-Small Cell Lung Cancer Tissue by Quantitative Assessment of Class III β-Tubulin Expression
Published 2024-10-01Get full textBackground. The cytoskeletal protein β-tubulin class III (Tubb3) is associated with tumor resistance to taxanes and vinca alkaloids, as well as with the metastatic potential of neoplasm, however, data from immunohistochemical analysis of Tubb3 expression in non-small cell lung cancer (NSCLC) tissue...
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Correlation of quantitative measures of estrogen receptor α and β expression in non-small cell lung cancer tissue with clinical characteristics of the disease
Published 2021-08-01Get full textThe expression level of estrogen receptors (ERα and ERβ) in surgical tumor biopsy specimens from 167 patients with non-small cell lung cancer (NSCLC) was quantified by flow cytometry-based immunofluorescence analysis. ERα and ERβ expression was revealed in all the tumor samples investigated. The level...
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Survival Outcomes in Patients after Radical Surgery for Non-Small Lung Cancer: an 8-year Study at N. N. Blokhin Cancer Research Center
Published 2021-05-01Get full textIn the study of 125 patients after radical surgery for non-small cell lung cancer (NSCLC), distinctive clinicopathological parameters of this disease were found. Thus, the majority of patients with NSCLC were smokers (73%), men had significantly higher rate of the disease than women (80% vs 20%). Pat...
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Study of Ridostin Pro and Poly(I:C) as adjuvants that enhance the immunogenicity of an antitumor vaccine
Published 2024-07-01Get full textAim of the study: to compare the antitumor efficacy and immunogenicity of vaccines with the same antigens but different adjuvants: Ridostin Pro or Poly(I:C); to evaluate the effect of Ridostin Pro and Poly(I:C) on the cytokine profile of serum and the immunophenotype of mouse spleen cells. Material...
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Features of Sulfide Mineralization of the Hydrothermal System of Cape Fiolent (Southwestern Crimea)
Published 2024-06-01Get full textAs a result of generalization of geophysical studies, petro-paleomagnetic and structural-geomorphological analyses, as well as thermodynamic modeling, some features of ore formation in the hydrothermal system of Cape Fiolent (southwestern Crimea) under island arc conditions were revealed.It has been...
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Repetition of the Void Space Structure of Achimov Sandstones of the East Urengoyskoye Field in Artificially Created Geometry of a Silicon Microfluidic Chip
Published 2025-04-01Get full textIn this work, a unique technique for replicating the void structure of a low-permeability reservoir in a silicon microfluidic chip has been developed. This technique is qualitatively superior to all previous ones and provides full repeatability of key parameters of the void structure (permeability;...
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