Search Results - V. P. Zherdev
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On the 20th anniversary of the journal «Pharmacokinetics and Pharmacodynamics» by V. P. Zherdev
Published 2024-06-01.
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FROM THE EDITOR by V. P. Zherdev
Published 2017-03-01В этом номере журнала представлены работы по изучению фармакодинамики, фармакокинетики и механизма действия в основном новых, создаваемых лекарственных средств. В частности, цикл работ посвящён изучению антиаритмической, противофибрилляторной активности, а также механизма действия нового соединения...
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10th anniversary of the journal «Pharmacokinetics and pharmacodynamics» by V. P. Zherdev
Published 2014-04-01Перед Вами юбилейный номер журнала «Фармакокинетика и фармакодинамика», который является логическим продолжением журнала «Клиническая фармакокинетика», вышедшего впервые в 2004 году. На первом этапе мы считали, что наиболее важное внимание необходимо уделить исследованиям клинической фармакокинетики...
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FROM THE EDITOR by V. P. Zherdev
Published 2016-03-01Перед вами номер журнала, который в основном посвящён созданию новых оригинальных лекарственных препаратов в различных рядах химических соединений и обладающих разными видами фармакологической активности. В последние годы в нашей стране уделяется большое внимание созданию новых лекарственных средств...
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The influence of the pharmacokinetics and bioavailability of cyclo-L-propylglycine to the manifestation of its main pharmacological effects in experimental animals by S. S. Boyko, K. N. Koljasnikova, V. P. Zherdev
Published 2021-06-01In the article presented the results of research of the influence pharmacokinetics, bioavailability for CNS cyclo-L-prolylglycine to the manifestation of its main pharmacological effects in experimental animals.
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The study of the permeability of the blood-brain barrier for new neurotropic peptide drugs by V. P. Zherdev, S. S. Boyko, R. V. Shevchenko
Published 2019-01-01The paper presents the results of studies of penetration through the hemato-encephalic barrier (BBB) of rats of three new peptide drugs -modified analogues of endogenous neuropeptides and their active metabolites created in the research Zakusov institute of Pharmacology. Discussed the main physical-...
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Pharmacokinetics and neurotropic effects of cyclo-L-prolylglycine and its modified analogues by S. S. Boyko, V. P. Zherdev, K. N. Koliasnikova
Published 2022-01-01The review presents the results of studies on the pharmacokinetics, metabolism, and bioavailability of new neurotropic dipeptide cyclo-Lprolilglycine (CPG) and their pharmacological activity. It was shown that the pharmacologically active metabolite of the nootropic drug noopept cyclo-Lprolilglycine...
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Comparative study of pharmacokinetics and enzymatic resistance of the neuroprotective mean GZK-111 and noopept in rats by S. S. Boyko, K. N. Koliasnikova, V. P. Zherdev
Published 2022-12-01The article presents the results of studying the pharmacokinetics and enzymatic stability of a new pharmacologically active compound GZK-111– N-phenylacetyl-glycyl-L-proline ethyl ether in comparison with noopept – N-phenylacetyl-L-prolyl-glycine ethyl ether in rats. It has been shown that both comp...
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The relationship between the content of the potential psychopharmacological agent cyclo-L-prolylglycine in the brain of experimental animals and its antihypoxic effect by V. P. Zherdev, S. S. Boyko, K. N. Kolyasnikova
Published 2020-07-01In the study of strutural and intracellular distribution of cyclo-t-prolylglycine (CPG) in brain rats in experiments on mongrel white male rats, it was found that CPG determined more in the hippocampus and cerebral cortex with predominant localization in the nuclear fraction of the rat brain, in the...
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The Role of pharmacokinetics and biopharmaceutical investigations in the creation of a new dipeptide drugs (experimental investigation) by V. P. Zherdev, S. S. Boyko, R. V. Shevchenko, T. A. Gudasheva
Published 2017-02-01In the paper presents the results of investigations pharmacokinetics a new dipeptyds neuropsychotropics drugs modyficated analogues of endogenics neuropeptids analizes in posishin of pharmacokinetics their comparable wich endogenics neuropeptids and metodical pathways of their pharmacokinetics impru...
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Isoform CYP1A2, as a part of the cytochrome P450 superfamily by Y. G. Novickaya, V. P. Zherdev, A. O. Viglinskaya, A. A. Litvin
Published 2014-04-01The role of cytochrome P450 isoforms CYP1A2 and in the metabolism of caffeine is described. Caffeine pharmacokinetics data in humans and laboratory animals are presented. Examples of drug-drug interactions of cubstrate marker caffeine with different drugs are given.
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Dimeric dipeptide mimetics of BDNF loop 4 are potential antidepressants with novel mechanisms of action by T. A. Gudasheva, P. Yu. Povarnina, A. V. Tarasyuk, V. P. Zherdev, A. D. Durnev
Published 2025-01-01This review covers original research focused on the design, synthesis, and pharmacological evaluation of an innovative dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) loop 4 bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106). Developed using a proprietary appr...
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Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues by O. Yu. Kravtsova, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, V. P. Zherdev
Published 2022-07-01The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose of 100 mg/kg. The values of ALM-802 tissue availab...
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Pharmacokinetics of a potential antiepileptic drug GIZh-298 by G. B. Kolyvanov, A. A. Litvin, O. Yu. Kravtsova, O. G. Gribakina, V. P. Zherdev
Published 2024-08-01GIZh-298 pharmacokinetics was studied in rats after different dosage regimens.The aim of this study was to study GIZh-298 pharmacokinetics after its multiple intragastric administration.Methods. The study was conducted on outbred male rats. The concentrations of GIZh-298 in the blood plasma were det...
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Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9 by O. G. Gribakina, G. B. Kolyvanov, A. A. Litvin, A. O. Viglinskaya, V. P. Zherdev
Published 2020-04-01The role of cytochrome P450 isoforms CYP2C9 and in the metabolism of losartan described. Losartan pharmacokinetics data in humans and laboratory animals are presented. Examples of drug-drug interactions of substrate marker losartan of CYP2C9 of with different drugs are given. The results of studies...
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Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115 by V. P. Zherdev, S. S. Boyko, E. V. Blynskaya, K. G. Turchinskaya, T. A. Gudasheva, E. V. Ivannikova
Published 2014-04-01The paper presents the results of experimental studies of pharmacokinetics GB-115 after oral administration of crystalline and micronized substances and 4 new laboratory samples pharmaceutical compositions which differ in the technology of preparation and composition of excipients. It is shown that...
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The role of studies of interspecies differences pharmacokinetics in the creation of new peptide drugs by V. P. Zherdev, S. S. Boyko, R. V. Shevchenko, P. O. Bochkov, O. V. Gribakina, S. Yu. Raskin
Published 2018-02-01Resume. The paper presents literature data about the interspecific differences of the pharmacokinetics of peptide drugs and the results of our own studies on the inter-specific features of the pharmacokinetics of the 3 modified analogues of endogenous neuropeptides (noopept, dilept and GB-115) in an...
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Study the pharmacokinetics and bioavailability in the creation of new original drugs peptide structures and their optimum dosage forms by E. V. Ivannikova, V. P. Zherdev, S. S. Boyko, E. V. Blynskaya, K. G. Turchinskaya, K. V. Alekseev
Published 2013-09-01The review focuses on the pharmacokinetics and bioavailability studies for creating new original drugs peptide structure. Much attention is paid to methods for the quantitative determination of peptide compounds in biological material, the study of their pharmacokinetic characteristics, factors that...
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Quantification of a potential anticonvulsant drug GIZh-298 in rat plasma by liquid chromatography-mass spectrometry by P. O. Bochkov, O. Yu. Kravtsova, G. B. Kolyvanov, A. A. Litvin, S. S. Boyko, V. P. Zherdev
Published 2022-12-01GIZh-298 is a new derivative of 4-phenylpyrrolidone with anticonvulsant and nootropic effects. A selective and sensitive HPLC-MS technique for the quantitative determination of GIZh-298 in rat blood plasma has been developed and validated. The linearity of the technique was confirmed by a high corre...
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