Suchergebnisse - V. P. Masenko

Aim. To study rosuvastatin safety and effects on lipid profile (LP) in coronary heart disease (CHD) patients. Material and methods. The study included 30 males (mean age 57±9 years) with diagnosed CHD, Functional Class II-III stable effort angina, receiving adequate basic therapy. In all participant...

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Aim. To study the effect of treatment with inhaled nitric oxide (iNO) on the clinical status of patients with idiopathic pulmonary hypertension (IPH), and the profile of proinflammatory cytokines in peripheral blood. Material and methods. Patients with IPH (n=48) were included into the study. Evalua...

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Aim. To assess the effects of original statins as monotherapy or in combination with ezetimibe on the levels of proinflammatory cytokines and high-sensitive C-reactive protein (hsCRP) in patients with coronary heart disease (CHD) and hyperlipidemia (HLP). Material and methods. The study included 60...

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Aim. To assess the prognostic performance of the GRACE scale extended by cystatin C levels in the prediction of ischemic and hemorrhagic in-hospital complications among patients with acute coronary syndrome (ACS). Material and methods. In 160 ACS patients, admitted to the Moscow City Clinical Hospit...

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Aim. To study right ventricular (RV) structure and function, assessed by standard echocardiography (EchoCG), tissue myocardial Doppler (TMD) EchoCG, and natriuretic peptide (NUP) levels, in patients with pulmonary hypertension (PH) of various aetiology. Material and methods. The study included 102 P...

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Aim. To study 24-week Fixed dose combination of perindopril with indapamide (Noliprel®) therapy effects on parameters of 24-hour blood pressure monitoring (BPM), carbohydrate, lipid, and purine metabolism, tissue insulin sensitivity, and cerebral perfusion in patients with mild to moderate arterial...

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Aim. To study effects of therapy with bisoprolol (Concor®) and deproteinized hemoderivate (Actovegin®) on circadian blood pressure profile (CBPP), carbohydrate, lipid metabolism, and cerebral perfusion in patients with metabolic syndrome (MS) and mild arterial hypertension (AH). Material and methods...

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Aim. To study the associations between heart and pulmonary artery (PA) remodeling severity, according to echocardiography data, natriuretic peptide (NUP) levels, and renin-angiotensin-aldosterone system (RAAS) activation among patients with pulmonary hypertension (PH) of various etiology.Material an...

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Clinical and hemodynamic profile and neurohormonal indicators in patients with idiopathic pulmonary hypertension, depending on vasoreactivity reserve of pulmonary arteries. Objective: the main objective of our research work was an evaluation of clinical and hemodynamic profile, neurohormonal indicat...

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Aim. To assess perindopril antihypertensive effects and its influence on metabolic disturbances, myocardial structure, and cerebral perfusion (CP) in patients with mild to moderate arterial hypertension (AH) and metabolic syndrome (MS) (AH + MS). Material and methods. Thirty patients with mild to mo...

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Aim. To study the effect of treatment with metabolic corrector mildronate on lipid profile, inflammatory factors and endothelium function in patients with ischemic heart disease (IHD).Material and methods. 60 patients with IHD (stable exertional angina, II-IV functional class) were included in to th...

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Aim. To study content of resident progenitor cardiomyocytes in endomyocardial biopsy samples of patients with dilated cardiomyopathy (DCM) and heart failure (HF) at different disease stages and relate it to patient clinical characteristics.Material and methods. Resident progenitor cardiomyocytes wer...

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Aim. To assess the dynamics of vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF- 1) and VEGF receptor Flt-1 (sFlt-1 or sVEGF-R1) levels in coronary heart disease (CHD) patients before and after myocardial revascularization. Material and methods: We examined fasting ser...

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Aim. To assess the effectiveness of vildagliptin, its effects on visceral obesity (VO), carbohydrate and lipid metabolism parameters, and circadian profile (CP) of blood pressure (BP) in patients with metabolic syndrome (MS), Stage I arterial hypertension (AH), and impaired glucose tolerance (IGT)....

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Androgen deprivation therapy (ADT) with luteinizing hormone-releasing hormone agonists is the basis for drug treatment in patients with metastatic prostate cancer (PC). An accurate assessment of the response of the tumor and its metastases is of primary importance for making a clinical decision rega...

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Vasoprotective effectiveness of atorvastatin and clopidogrel was investigated in 29 patients with duplex scanning-verified carotid atherosclerosis. Clinical and instrumental examination included assessment of lipid profile, endothelial function, intima-media thickness, carotid atherosclerotic plaque...

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Aim. To compare effects of atorvastatin in the doses of 10 and 20 mg/d on lipid profile, C-reactive protein (hsCRP), fibrinogen levels, as well as vascular wall structure and function in patients with coronary heart disease (CHD) and primary hyperlipidemia (PHL). Material and methods. Fifty CHD and...

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Aim. To assess the effect of the sodium-glucose transport protein 2 inhibitor empagliflozin on exercise tolerance and left ventricular (LV) diastolic function in patients with heart failure with preserved ejection fraction (HFpEF) and type 2 diabetes (T2D).Material and methods. The present prospecti...

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Background. Levosimendan infusion can be used in the treatment of patients with acute decompensated heart failure (ADHF) with a reduction in cardiac output and signs of severe congestion/pulmonary edema.Aim. To study impact of levosimendan on renal function in patients with ADHF with reduced systoli...

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