Søgeresultater - V. A. Shevtsov
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1
Analysis of Efficacy and Safety of Tick-Borne Encephalitis Vaccines
Udgivet 2018-03-01Få fuldtekstThis article provides a review on efficacy and safety of tick-borne encephalitis vaccines licensed in the Russian Federation. It highlights that both Russian and imported tick-borne encephalitis vaccines demonstrate high immunogenicity, safety and epidemiological effectiveness in regions with hig...
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THE EPIDEMIOLOGICAL AND IMMUNOLOGICAL EFFECTIVENESS OF VACCINATION OF HEPATITIS A IN ORGANIZED GROUPS OF MILITARY PERSONNEL. IMMUNOLOGICALLY EFFECTIVE DOMESTIC VACCINE «HEP-IN-A-VA...
Udgivet 2012-12-01Få fuldtekstSince 2004 the incidence of hepatitis A of conscripts declined by more than 70 times, which happened primarily due to vaccination. The paper under review presents the characteristics of a phased strategy of specific prevention of hepatitis A, provides the comparative analysis of the immunological an...
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Comparative Analysis of Approaches to Assess the Quality of Inactivated Influenza Vaccines: Regulatory Requirements in the Russian Federation and European Union
Udgivet 2021-01-01Få fuldtekstThe experience with the influenza pandemic caused by strain A (H1N1) 2009 and the existing gaps in standardizing and evaluating the quality and effectiveness of vaccines for influenza prevention have led the European Union (EU) to recognize the need to review / update the current guidelines on requi...
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Retrospective Analysis of Viral Hepatitis B Incidence in Russia from 2013 to 2017 in the Context of Preventive Vaccination
Udgivet 2018-12-01Få fuldtekstThe article presents the results of a retrospective analysis of viral hepatitis B incidence in the Russian Federation from 2013 to 2017, taking into account the use of vaccines included into the National Immunisation Schedule and the Immunisation Programme in Case of Epidemic Outbreaks. The analysis...
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Promising opportunities to improve polio vaccines
Udgivet 2022-07-01Få fuldtekstPolioviruses belong to Enterovirus C species and cause severe lesions of the nervous system. In the post-polio eradication era, the World Health Organisation recommends inactivated polio vaccines for effective long-term protection of the population. In order to meet the needs of global health, it is...
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Rotavirus Epidemiology and Vaccination Tactics
Udgivet 2019-06-01Få fuldtekstRotavirus infection is a widespread cause of severe gastroenteritis in children in low-income countries. Specific prophylaxis in young children has become the most important means of combating severe rotavirus gastroenteritis. The review presents current data on the molecular biology and genetic div...
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Experimental Study of Grippferon Antiviral Activity Against Mexican Pandemic Influenza Virus A/H1N1/2009 in vitro
Udgivet 2020-05-01Få fuldtekstAnalysis of the efficacy of Grippferon vs. the reference drugs Realdiron and Reaferon-EC against the influenza virus A(H1N1)/2009 in susceptible static cell cultures showed that in the concentrations tested it was efficient in inhibition of the virus cytopathic activity and generation of specific he...
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Vaccine Safety and Efficacy in Preventing Rotavirus Infection
Udgivet 2019-12-01Få fuldtekstThe rotavirus infection causes acute gastroenteritis and is a major cause of lethal severe dehydrating diarrhoea in children under 5 years of age worldwide. Live attenuated rotavirus vaccines are the only means of preventing severe forms of the disease. The aim of the study was to analyse the twenty...
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An Outbreak of a New Infectious Disease COVID-19: β-coronaviruses as a Threat to Global Healthcare
Udgivet 2020-03-01Få fuldtekstCoronaviruses are the largest group of known positive-strand RNA viruses. Coronavirus infection can affect various animal species, as well as humans. Over the past two decades, coronaviruses have caused epidemic outbreaks of two respiratory diseases: the Middle East Respiratory Syndrome and Severe A...
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Epidemiology of hepatitis A and vaccination policy
Udgivet 2018-02-01Få fuldtekstHepatitis A (HA) is an acute infectious disease of the liver caused by the hepatitis A virus (HAV). HA disease incidence rate is closely linked to the social and economical development. The results of seroepidemiologic studies show that the prevalence of anti-HAV antibodies in population ranges from...
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The analysis of a long-term experience of studying inactivated cell-culture vaccines for preventing tick-borne encephalitis of domestic and foreign manufacture in terms of specific...
Udgivet 2018-02-01Få fuldtekstThe analysis of the use of the method for the evaluation of specific (immunogenic) activity of vaccines for preventing tick-borne encephalitis (TBE vaccines) against protective dilution (PD50) and the minimum immunizing dose (MID50) has been performed. The method was standardized and submitted to th...
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Cell cultures in replacement therapy
Udgivet 2018-02-01Få fuldtekstCell replacement therapy is one of the top priority areas of modern medicine, which is aimed at restoring the structure and functions of damaged tissues by transplanting cells grown in vitro . The article summarizes data obtained in several studies of diploid cell lines (allogeneic fibroblasts) used...
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The Results of Re-certification of Reference Standard Sample Used for the Examination of Quality Smallpox Vaccines
Udgivet 2016-12-01Få fuldtekstThe article presents the results of research quality of drugs for the prevention of smallpox during the period from 2007 to 2015 years, where the reference standard uses industry standard of activity, specificity (identification) and necrotic activity of smallpox vaccine, on indicators: «Specific ac...
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Post-approval variations to dossiers for vaccines: analysis of regulatory and methodological approaches used in the Russian Federation and abroad
Udgivet 2019-03-01Få fuldtekstThe management of post-approval changes to registration dossiers for medicinal products is one of the most important factors for ensuring sustainable quality, safety and efficacy of medicines. Competent authorities that use the module format of the registration dossier, i.e. the regulatory authoriti...
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Analysis of biological and genetic stability of tick-borne encephalitis strain 205 used in the production of tick-borne encephalitis vaccines EnceVir and EnceVir Neo for children
Udgivet 2018-02-01Få fuldtekstThe article presents the results of a long-term study of biological and genetic stability of tick-borne encephalitis strain 205 which is used by the FSUE «SPA «Microgen» to produce tick-borne encephalitis vaccines EnceVir (for adults) and EnceVir Neo for children, both of which are tissue cultured,...
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Vaccines with adjuvants. Preclinical studies
Udgivet 2018-02-01Få fuldtekstThe paper presents the data on safety and efficacy assessment of adjuvants and vaccines with adjuvants at the stages of development and preclinical studies based on international recommendations. The presence of an adjuvant in vaccine content ensures higher expressing and prolonged specific immunity...
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Mycoplasma - contamination of cell cultures
Udgivet 2018-02-01Få fuldtekstThe safety of biological products derived from animal cells is associated with the properties of the cells themselves or their components, as well as with the possible presence of contaminants of microbial and viral origin. The suitability of cell substrate for production of prophylactic preparation...
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Approaches to Reduce Adverse Effect of Vaccinia Virus in Orally Immunized Mice
Udgivet 2016-03-01Få fuldtekstObjective of the investigation was to model the adverse action of vaccinia virus (VV), caused by oral immunization of mice and to evaluate efficacy of its reduction, using therapeutic and prophylactic drugs. Materials and methods. Virological and immunological research methods were used. Results and...
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