Search Results - Tong Chen

N¹-methyladenosine (m¹A) serves as a critical regulatory modification in plant mRNA. In <i>Arabidopsis</i>, the TRM61/TRM6 complex functions as m¹A58 methyltransferase writers essential for organogenesis, reproduction,...

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In response to the limitations of traditional static reliability analysis methods in characterizing the reliability changes of the Integrated Power System, this paper proposes a time-varying reliability analysis framework based on a Dynamic Bayesian Network. By embedding a multi-physics coupled degr...

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Substitution strategy is a fundamental component of tactical adjustments in soccer matches. Since the official introduction of the five-substitution rule in 2020, substitute players have faced increased performance demands. This study examines 2,125 substitution events (excluding goalkeepers) from t...

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BackgroundChemotherapy alone exhibits suboptimal efficacy in patients with treatment-naïve advanced gastric cancer (GC). Randomized controlled trials (RCTs) have demonstrated that combining Programmed Cell Death Protein-1 (PD-1) blockade with chemotherapy significantly improves overall survival (OS)...

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ABSTRACT Investigating the differences among plant functional types (PFTs) and their responses to N deposition is crucial for predicting carbon and nutrient cycles and improving forest management strategies. Our research aimed to examine the decomposition rates and nutrient loss rates of leaf litter...

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Purpose To explore the N6-methyladenosine (m6A) modification mechanism of taurine upregulated gene 1 (TUG1) and whether methyltransferase 3 (METTL3) can promote peroxisome proliferators-activated receptor γ coactivator 1 alpha (PGC-1α) transcription and alleviate mitochondrial dysfunction.Methods In...

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The origin of the correlation between the effective spins ( χ _eff ) and mass ratios ( q ) of LIGO–Virgo–KAGRA’s binary black holes (BBHs) is still an open question. Motivated by the recent identification of two subpopulations of the BBHs, in this work we investigate the potential χ _eff – q correla...

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Polygonatum cyrtonema flour (PCF) is rich in active substances such as flavonoids, polysaccharides, and trace elements, which can be added to food to enhance its nutritional value while imparting product quality. In this study, we investigated the effects of PCF on the quality and characteristics of...

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Black carbon (BC) affects the Arctic climate via aerosol‒radiation‒cloud interaction and snow/ice albedo feedback. Fires have become a substantial source of the Arctic BC in recent years, while the radiative effects of BC in the Arctic due to the recent extreme fires remain unclear. In this study, t...

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Abstract Background Metformin is a widely used antidiabetic agent for obesity-related type 2 diabetes mellitus, providing significant health benefits such as reduced blood glucose levels and body weight. Emerging evidence suggests that metformin may play a beneficial role in delaying aging. However,...

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Abstract Actin‐ and microtubule‐based transport systems are essential for the trafficking of endocytic viruses and cargoes. Microtubules facilitate long‐distance transport; however, the precise role of actin dynamics and its regulators during virus entry, particularly in the transit process, remains...

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Swine H1N1/2009 influenza is a highly infectious respiratory disease in pigs, which poses a great threat to pig production and human health. In this study, we investigated the global expression profiling of swine-encoded genes in response to swine H1N1/2009 influenza A virus (SIV-H1N1/2009) in newbo...

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Background Public neoantigens, including KRAS, TP53, and PIK3CA mutations, which are shared across various tumor types, have demonstrated significant immunogenicity and offer great promise for cancer immunotherapy. Clinical trials targeting these public neoantigens have yielded encouraging results,...

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Our previous investigation revealed that Coenzyme Q0 (CoQ0), a quinone derivative from Antrodia camphorata, triggered ROS-dependent voltage-dependent anion channel 1 (VDAC-1)-mediated apoptosis in human promyelocytic leukemia (HL-60) cells. This research examined the efficacies of CoQ0 (0–7 μM) on a...

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PurposeBreast cancer (BRCA) is the most common cancer in women. Overexpression of long non-coding RNA Prostate cancer-associated transcript 7 (PCAT7) in BRCA was correlated with an unfavorable prognosis. Consequently, investigating the function and prognostic significance of PCAT7 in BRCA has become...

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