Search Results - Taichi Isobe

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    Development of iPSC-derived T cells targeting EGFR neoantigens in non-small cell lung cancer

    Development of iPSC-derived T cells targeting EGFR neoantigens in non-small cell lung cancer by Kouta Niizuma, Toshinobu Nishimura, Jonathan Villanueva, Laura Amaya, Jonas L. Fowler, Taichi Isobe, Yusuke Nakauchi, Brandon Saavedra, Haojun Xu, Mahito Nakanishi, Adam C. Wilkinson, Kyle M. Loh, Joseph B. Shrager, Hiromitsu Nakauchi

    Published 2025-09-01

    A long-sought goal of cancer immunotherapy is to mass-produce T cells that specifically target tumor neoantigens. One decisive challenge is the identification of neoantigens derived from cancer driver genes. Here, we identify T cells that recognize the NSCLC-associated EGFR C797S mutation, which con...

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