Search Results - T. V. Sleptsova

The reviewed Jewish Philosophy in an Analytic Age is a unique collection of essays that combine analytical philosophy to the Jewish religion. Analytical approach has been widely applied to Christianity since the 1980s and marked the legitimization of analytical philosophy of religion. This turn is p...

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The article presents a case report of a patient with juvenile rheumatoid arthritis refractory to the treatment with metothrexate. Combined therapy with metothrexate and leflunomide induced development of unfavorable effects resulted in cancellation of leflunomide. Successful administration of biolog...

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The article presents a case of successful use of therapeutic monoclonal antibodies to interleukin 1 (canakinumab) at severe systemic juvenile idiopathic arthritis. Canakinumab treatment promptly provided reduction in clinical and laboratory disease activity indicators, increase in life quality, deve...

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The article represents a history case of successful usage of tolicizumab (anti-interleukin 6 monoclonal antibodies) in treatment of severe systemic juvenile idiopathic arthritis, resistant to previous standard antirheumatic therapy. Tocilizumab treatment led to distal joints function restoration and...

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A history case of severe juvenile ankylosing spondyloarthritis, characterized by rapid development of asymmetric polyarticular syndrome, sacroiliitis, patient’s incapacity and low quality of his and his family life, is discussed in this article. The activity of pathological process was managed to be...

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The article presents a case of successful application of a monoclonal antibodies drug to interleukin 6 receptors (tocilizumab) at severe systemic juvenile idiopathic arthritis with the development of secondary hemophagocytic syndrome. Tocilizumab treatment secured a decrease in clinical and laborato...

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The article describes a case with a severe course of oligoarticular juvenile idiopathic arthritis with the development of contracture and destructive articular alterations. The successful use of methotrexate (15mg/m2 of body surface per week, subcutaneously) in a child with early arthritis (disease...

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The article presents a case of successful use of a preparation of monoclonal antibodies to interleukin 6 receptors (tocilizumab) at asevere systemic juvenile idiopathic arthritis. Tocilizumab treatment promptly provided decrease of clinical and laboratory parametersof the disease activity, increase...

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The article describes a case of polyarticular juvenile idiopathic arthritis lesions of the cervical spine. This clinical example demonstrates the high efficiency of tocilizumab in a patient with polyarticular juvenile idiopathic arthritis with lesions of the cervical spine. After the first injection...

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This article presents clinical case of early manifestation of juvenile oligoarthritis with rapid contracture and destructive joint changes formation. Methotrexate was administered IM 15 mg/m2 once a week. After 3 months of treatment — acute inflammatory changes in the joint were relieved as well as...

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The article contains a history case of early onset of pauciarticular juvenile rheumatoid arthritis resistant to standard immunosuppressive treatment with methotrexate at a dose of 15 mg/m2 per week orally, with development of contractures and destructive changes in the joints. The resistance was suc...

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The article describes a case of an early debut and difficult treatment of systemic juvenile idiopathic arthritis resistant to peroral glucocorticoids. The described clinical example demonstrates the successful use of tocilizumab, a monoclonal antibody drug, against interleukin-6 receptors. After the...

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The article presents results of a study of effectiveness and safety of infliximab — monoclonal antibodies to the tumor necrotizing factor (TNF) in treatment of 100 patients11 months — 17 years old with early and late articular types of juvenile rheumatoid arthritis. The duration of treatment was 3 m...

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A clinical case of severe juvenile scleroderma is represented in this article. The patient had a high activity and aggressive course of disease, he was resistant to steroid, cyclophosphomide and methotrexate therapy in combination with drugs, improving blood circulation. The authors describe the suc...

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This article contains observation of severe poliarticular variant of juvenile rheumatoid arthritis, resistant to glucocorticoid treatment and classic immunosuppressive therapy. There is a description of biologic treatment — with chimeriс antibodies to TNF α — infliximab in a patient with protracted...

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The article presents a case of early onset of systemic juvenile arthritis with active articular syndrome, severe systemic manifestations and high level of laboratory disease activity indicators. It describes successful use of methotrexate for intramuscular administration in the dose of 25 mg/m2 of b...

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This article describes a case of successfully used tocilizumab (interleukin 6 receptors monoclonal antibodies) in a two-year patient with severe systemic juvenile idiopathic arthritis resistant to oral and parenteral glucocorticoids, nonsteroidal anti-inflammatory drugs, and methotrexate. Just after...

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The article presents an observation of one of the most common autoinflammatory syndromes — TRAPS (periodic syndrome associated with a mutation in the TNF α receptor gene). During a molecular-genetic examination of a 9-year-old child, a c.337_339del deletion in the heterozygous state of the TNFRSF1A...

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The article describes a case of torpid course of oligoarticular juvenile idiopathic arthritis (JIA) and the successful use of soluble receptorsf or tumor necrosis factor alpha (TNF) — etanercept — during its treatment. After 4 weeks of treatment the patient returned to normal laboratory indices of t...

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The article presents a case report of severe course of nodular polyarteritis. The disease was highly active, aggressive, and refractory to treatment with corticosteroids and cyclophosphamide combined with plasmapheresis and drugs for microcirculation improvement. The treatment with chimerical anti-C...

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