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    Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period

    Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period by Amalia J. Peterson, Yunyi Sun, Derek B. Archer, Hailey A. Adegboye, Elizabeth E. Moore, Isabella Deberghes, Kimberly R. Pechman, Niranjana Shashikumar, W. Hudson Robb, Abigail W. Workmeister, T. Bryan Jackson, Dandan Liu, Logan Dumitrescu, L. Taylor Davis, Bennett A. Landman, Kaj Blennow, Henrik Zetterberg, Timothy J. Hohman, Angela L. Jefferson

    Published 2025-04-01

    Abstract INTRODUCTION Neuroinflammation may have sex‐specific effects on white matter injury and impact the development of dementia. METHODS Human chitinase‐3‐like protein‐1 (YKL‐40) concentrations at baseline were related to white matter hyperintensity (WMH) volume, free water (FW), and FW‐correcte...

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